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Human Renal Proximal Tubule Epithelial Cell Line

Product Name

Human Renal Proximal Tubule Epithelial Cell Line

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Cat.No

ABI-TC033D

Species

Human

Size/Quantity

1 vial

Biosafety Level

2

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

The cells are derived from primary human renal proximal tubule epithelial cells (RPTECs) Immortalised by two lentiviral vectors carrying the human telomerase (hTERT) and the SV40 T antigen (Tag).Both the hTERT and Tag genes in the lentiviral vectors are flanked by loxP sites. Transient Cre expression in cells leads to efficient proviral deletion and upregulation of some renal specific activities. Removal of the genes for cell immortalization also significantly decreases the rate of cell proliferation and ultimately leads to cell senescence, suggesting that the cell cycle control remains intact in cells despite continuous passage of these cells in culture.

Disease

Normal

Source Organ

Kidney

Recommended Medium And Supplement
Citation Guide

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Application

For research use only

Immortalization Method

two lentiviral vectors carrying the human telomerase (hTERT) and the SV40 T antigen (Tag)

Growth Conditions

37 ℃, 5% CO2

Cell Type

Epithelial

Growth Mode

Adherent

Product Type

Immortalized Cell Line

Product Image AcceGen Frozen Cells & Cell Lines 1 vial
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