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Human Urothelial Cells

ImageAcceGen cells & cell lines
Product Name

Human Urothelial Cells

Product Code

HUC

Cat.No

ABC-TC3861

Species

Human

Biosafety Level

1

Size/Quantity

1 vial

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

The urothelial cells, the cells lining the surface of the urinary bladder, are comprised of a unique cell type with high plasticity and a variety of cell functions. They are the first line of bladder defense and serve as an interface between pathogens that is equipped with several defense mechanisms to prevent adherence of pathogens and maintain impermeability to urinary solutes. The urothelial cells express both estrogen receptor-alpha and beta, epidermal growth factor receptor and fibroblast growth factor receptor, these receptors play a major role on urothelial cell response to injury and infection. They also release a number of cytokines and other immune system mediators and this newly recognized immunoregulatory potential of the urothelial cell warrants further investigation through the application of two recent developments: 1) the ability to culture normal urothelial cells in the laboratory and 2) the understanding of how immunoregulatory communications are generated for the biological functions of urothelial cells through signal transduction pathways.HUC from AcceGen Research Laboratories are isolated from the human bladder. HUC are cryopreserved at passage one and delivered frozen. Each vial contains >5×10^5 cells in 1 ml volume. HUC are characterized by immunofluorescent method with antibodies to cytokeratin-18, -19 and vimentin. HUC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HUC are guaranteed to further expand for 15 population doublings in the condition provided by AcceGen Research Laboratories.

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Citation Guide

If the product is used for publication, it should be cited in the publication as: "AcceGen Cat.# XXX-0000". In addition, click here to submit your paper’s PubMed ID (PMID) to get a $100 coupon.

Application

For research use only

Product Type

Urethral Cells

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