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Immortalized Cell Lines

Immortalized Human Brain Microvascular Endothelial Cells

  • For research use only

Cat No.

ABC-H0025X
Product Type

Immortalized Cell Line
Cell Type

Endothelial
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Brain
Disease

Normal
Storage

Liquid Nitrogen

Immortalized Human Brain Microvascular Endothelial Cells support blood-brain barrier modeling, angiogenesis assays, and neurovascular drug studies.

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  • Immortalized Human Brain Microvascular Endothelial Cells
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Home | Immortalized Cell Lines | Immortalized Human Brain Microvascular Endothelial Cells

Description

Immortalized Human Brain Microvascular Endothelial Cells (IM-HBMEC) are developed by immortalizing primary human brain microvascular endothelial cells (HBMECs) using the SV40 Large T antigen. These cells maintain the immune barrier properties of primary HBMECs. IM-HBMEC cells exhibit a polygonal, cobblestone-like morphology and grow as adherent monolayers. They can undergo serveal passages without senescence, unlike primary HBMECs, which undergo early senescence after the 3rd passage. The IM-HBMEC cell line is non-tumorigenic and does not exhibit metastatic behavior. It mimics primary HBMECs in assays such as leukocyte migration, cytokine production, and reactions to astrocyte coculture. Flow cytometry shows no significant differences in immune responses compared to primary HBMECs.

Product Code

Immortalized Human Brain Microvascular Endothelial Cells, iHBMECs, Imm-HBMEC, hBMVEC-Imm, SV40-HBMEC, hTERT-HBMEC
Species

Human
Cat.No

ABC-H0025X
Product Category

Immortalized Cell Lines
Size/Quantity

1 vial
Cell Type

Endothelial
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Brain
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Immortalized Cell Line
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Immortalized Human Brain Microvascular Endothelial Cells (IM-HBMEC) provide a cost-effective and reliable in vitro model of the blood-brain barrier (BBB). These cells exhibit high barrier integrity, immune cell migration, and cytokine responses, closely mimicking the human BBB endothelial phenotype. IM-HBMECs are valuable for studying CNS infections and serve as a practical alternative to primary brain endothelial cells in BBB research.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Frequently Asked Questions

  • Do you perform routine QC on Immortalized Human Brain Microvascular Endothelial Cells with expression profiling and morphological checks?

    Yes, we perform routine QC on these immortalized cells, including re-checking the expression of vWF and examining cell morphology.

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High Viability
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Precision and Reliability
To support a consistent result
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