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Immortalized Human Brain Microvascular Endothelial Cells

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Immortalized Human Brain Microvascular Endothelial Cells

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1 vial

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Dry Ice


Liquid Nitrogen


Immortalized Human Brain Microvascular Endothelial Cells (IM-HBMEC) are a specialized cell line developed by immortalizing primary cells using SV40 Large T antigen. These cells have been extensively characterized and demonstrated to maintain the immune barrier properties of primary HBMECs. Flow cytometric analysis comparing IM-HBMEC with primary HBMECs revealed no significant differences in leukocyte migration responses or inflammatory cytokine production. Additionally, IM-HBMECs exhibited similar responses to astrocyte coculture, leukocyte stimulation, and inflammatory cytokine treatment. The immortalized cells showed remarkable longevity, with the ability to undergo more than 30 passages compared to the senescence observed in primary cells after the 3rd passage.


Why choose Immortalized Human Brain Microvascular Endothelial Cells from AcceGen?

AcceGen’s Immortalized Human Brain Microvascular Endothelial Cells offer high viability, advanced engineering, stability, sterile conditions, and confirmed absence of viruses (Hepatitis, HPV, Herpes, HIV) and mycoplasma contamination. Trust AcceGen for reliable, safe, and top-quality research.



Source Organ


Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Recommended Medium And Supplement
Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).



IM-HBMECs offer a cost-effective and practical solution for constructing in vitro models of the blood-brain barrier (BBB). These immortalized cells exhibit exceptional fidelity in terms of barrier resistance, immune migration profiles, and responsiveness to inflammatory cytokines. With their specialized BBB endothelial phenotype, this newly established human cell line provides a readily available in vitro model for studying the properties of the human BBB. IM-HBMECs are particularly valuable for investigating central nervous system infections, offering a valuable alternative to primary brain endothelial cells as a reliable model for studying the blood-brain barrier in such studies.

Growth Conditions

37 ℃, 5% CO2

Cell Type


Growth Mode


Product Type

Immortalized Cell Line

Product Image AcceGen Frozen Cells & Cell Lines 1 vial
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