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MDA-MB-453

Product Name

MDA-MB-453

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Product Code

MDA-MB 453; MDA MB 453; MDA-MB453; MDAMB453; MDA-453; MDA453; MD Anderson-Metastatic Breast-453

Cat.No

ABC-TC0656

Species

Human

Size/Quantity

1 vial

Biosafety Level

1

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

MDA-MB-453 cells were derived in 1976 from a female patient with metastatic breast cancer. These cells have a deletion mutation in the p53 gene, resulting in the absence of the p53 protein. They exhibit aneuploidy, with abnormal numbers of chromosomes, including the absence or under-representation of certain normal chromosomes. Marker chromosomes, with structural abnormalities, are also present. Over time, the cell population has transitioned from near-diploid to tetraploid. MDA-MB-453 cells overexpress fibroblast growth factor (FGF) receptors. Overall, these cells represent a breast cancer cell line with distinct genetic, chromosomal, and receptor expression characteristics.

Why choose MDA-MB-453 from AcceGen?

Our MDA-MB-453 cell product is sterile, being negative for bacterial, fungal, mycoplasma, and human pathogen contamination. It ensures high quality, viability, and adheres to stringent production standards. The cells exhibit a healthy morphology, and their identity is confirmed using Short Tandem Repeat (STR) analysis.

Source Organ

Breast

Recommended Medium And Supplement
Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

FOR RESEARCH USE ONLY

MDA-MB-453 cells have diverse applications in breast cancer research. They are used to examine the anti-proliferative effects of drugs and uncover the molecular mechanisms behind therapeutic efficacy. Additionally, these cells aid in studying tumorigenesis, endocrine resistance signaling, and identifying potential markers for breast cancer. By assessing drug responses, investigating tumor pathways, and analyzing gene and protein profiles, MDA-MB-453 cells contribute to understanding breast cancer biology and advancing targeted therapies. Their versatility makes them valuable tools in research aiming to improve treatment outcomes for breast cancer patients.

Growth Conditions

37 ℃

Cell Type

Epithelial

Growth Mode

Adherent

Product Type

Human Breast Cancer Cell Lines

Product Image

mda-mb-453 cell line

AcceGen product mda-mb-453 cell line

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