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Mouse Hepatic Stellate Cells

Product Name

Mouse Hepatic Stellate Cells

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Product Code

MHSteC

Cat.No

ABC-TC3927

Species

Mouse

Size/Quantity

1 vial

Biosafety Level

1

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

Mouse Hepatic Stellate Cells (MHSC) are liver-specific mesenchymal cells derived from mouse liver, constituting 5-8% of total liver cells. Integral to liver homeostasis, maintenance, and regeneration, they excel at retinol metabolism. While quiescent in health, they harbor ample vitamin A lipid droplets, a major systemic reserve. However, in response to liver injury, MHSCs transition into an activated state marked by proliferation, contractility, and chemotaxis. This activation contributes to liver fibrosis, underpinning ailments like hepatitis B and C, fatty liver disease, and diabetes. Consequently, understanding MHSCs holds pivotal insights into treating chronic liver diseases and their associated complications, including cirrhosis.

 

Why choose Mouse Hepatic Stellate Cells from AcceGen?

Mouse Hepatic Stellate Cells from AcceGen are cryopreserved at passage one, ensuring cell viability upon delivery. They have been rigorously characterized through immunofluorescence targeting desmin and/or α-actin, ensuring their authenticity. Importantly, they have been screened and found negative for mycoplasma, bacteria, yeast, and fungi, ensuring their purity. AcceGen provides the assurance of successful culture continuation under the recommended conditions, making them a dependable choice for your research endeavors.

Disease

Normal

Source Organ

Liver

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Recommended Medium And Supplement
Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

FOR RESEARCH USE ONLY

Mouse Hepatic Stellate Cells offer a robust model system for delving into various facets of liver metabolism and pathophysiology. Their application spans diverse cell-based assays, including toxicity assessment, drug screening, and metabolic studies. They emerge as a crucial resource in the study of liver fibrosis, offering insights that could drive innovative therapeutic strategies for hepatic fibrosis treatment, ultimately aiming to enhance patient outcomes and mitigate the impact of chronic liver injury.

Growth Conditions

37 ℃, 5% CO2

Cell Type

Stellate Cell

Growth Mode

Adherent

Product Type

Mouse Primary Cells

Product Image AcceGen Frozen Cells & Cell Lines 1 vial
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