Mouse Hepatic Stellate Cells

Mouse Hepatic Stellate Cells (MHSC) are liver-specific mesenchymal cells derived from mouse liver, constituting 5-8% of total liver cells. Integral to liver homeostasis, maintenance, and regeneration, they excel at retinol metabolism. While quiescent in health, they harbor ample vitamin A lipid droplets, a major systemic reserve. However, in response to liver injury, MHSCs transition into an activated state marked by proliferation, contractility, and chemotaxis. This activation contributes to liver fibrosis, underpinning ailments like hepatitis B and C, fatty liver disease, and diabetes. Consequently, understanding MHSCs holds pivotal insights into treating chronic liver diseases and their associated complications, including cirrhosis.

Why choose Mouse Hepatic Stellate Cells from AcceGen?

Mouse Hepatic Stellate Cells from AcceGen are cryopreserved at passage one, ensuring cell viability upon delivery. They have been rigorously characterized through immunofluorescence targeting desmin and/or α-actin, ensuring their authenticity. Importantly, they have been screened and found negative for mycoplasma, bacteria, yeast, and fungi, ensuring their purity. AcceGen provides the assurance of successful culture continuation under the recommended conditions, making them a dependable choice for your research endeavors.