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| Species | Rat |
| Cat.No | ABC-TC4214 |
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
| Product Category | Primary Cells |
| Size/Quantity | 1 vial |
| Cell Type | Schwann Cell |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Peripheral Nervous System |
| Disease | Normal |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Rat Primary Cells |
Rat Schwann Cells (RSCs) are glial cells derived from the peripheral nervous system (PNS), which are mainly isolated and cultured from the sciatic nerve or other peripheral nerve tissues of rats. Morphologically, RSCs are usually bipolar or tripolar spindle-shaped in vitro culture, with slender cell bodies and obvious processes, and often grow in a monolayer adherent manner. The main functions of RSCs include forming myelin sheaths to wrap axons to promote efficient conduction of nerve signals, secreting neurotrophic factors (such as NGF and BDNF) to support neuronal survival and regeneration, and participating in the injury repair and microenvironment regulation of PNS. After peripheral nerve injury, RSCs can dedifferentiate into a repair state, guide axon regeneration and rebuild the myelin sheath structure.
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Rat Schwann Cells offer a valuable model for developmental studies and have clinical implications in neuropathies, nerve regeneration, and central nervous system (CNS) repair. Their biology is crucial to understand for potential therapeutic applications. Schwann cells or their precursors show promise in facilitating CNS repair through implants and bioengineered scaffolds. Due to their unique properties and interactions with neurons, they play a significant role in neurology, tissue engineering, and regenerative medicine. By exploring schwann cell biology, we can advance our understanding and develop innovative approaches for addressing neurological disorders and promoting nerve regeneration.
