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| Product Code | SAOS-2; SAOS 2; Saos 2; Saos2; SaOs2; SAOS2; Sarcoma OSteogenic-2; SaOS; SAOS |
| Species | Human |
| Cat.No | ABC-TC1006 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial-like |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Bone |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Bone Cancer Cell Lines |
Saos-2 is a human osteosarcoma cell line derived from the primary tumor of an 11-year-old Caucasian female. These cells exhibit an epithelial-like morphology and grow as an adherent monolayer with a doubling time of approximately 48 hours. Characterized by a hypotriploid karyotype, with a modal chromosome number of 56. Saos-2 demonstrate key osteoblastic properties, including high alkaline phosphatase (ALP) activity and production of bone-specific proteins such as osteocalcin and osteopontin. They also express functional receptors for 1,25-dihydroxyvitamin D3 and parathyroid hormone (PTH), enabling cAMP-mediated responses upon hormonal stimuli. Although derived from a tumor, Saos-2 cells do not show tumorigenicity in immunocompromised mice under standard subcutaneous inoculation. Under osteogenic culture conditions, they can mineralize extracellular matrix, making them valuable for modeling bone microenvironment interactions.
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The Saos-2 cell line has served as a pivotal model of late-stage osteoblastic differentiation, offering unique advantages in bone biology and cancer research. Despite their osteosarcoma origin, Saos-2 cells closely mimic mature human osteoblasts and are characterized by robust alkaline phosphatase (ALP) activity and osteogenic gene expression. Saos-2 cells are particularly useful in studies of bone mineralization, hormonal regulation of osteoblasts, and the interactions between tumor cells and the bone microenvironment. Notably, in comparative analyses, Saos-2 cells exhibited one of the most mature osteoblastic phenotypes among osteosarcoma-derived lines, highlighting its utility in unraveling key molecular events associated with osteogenesis, bone modeling, and skeletal metastasis.
