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Product Code | SF-126; SF 126 |
Species | Human |
Cat.No | ABC-TC1017 |
Product Category | Tumor Cell Lines |
Size/Quantity | 1 vial |
Cell Type | Fibroblast-like |
Shipping Info | Dry Ice |
Growth Conditions | 37 ℃, 5% CO2 |
Source Organ | Brain |
Biosafety Level | 1 |
Storage | Liquid Nitrogen |
Product Type | Human Nerve Tumors Cell Lines |
The SF-126 cell line is a human glioblastoma model originally isolated from a 50-year-old female patient’s astrocytoma tissue in the left frontal lobe. These tumor cells exhibit fibroblast-like morphology with adherent growth properties. Karyotype analysis reveals aneuploidy with chromosome counts ranging from 43 to 47, indicative of genomic instability characteristic of aggressive gliomas . SF-126 lacks glial fibrillary acidic protein (GFAP) expression due to promoter hypermethylation, a feature associated with high-grade astrocytomas. The cells demonstrate tumorigenic potential in xenograft models, with studies showing intracranial tumor formation in immunocompromised mice.
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SF126 cells serve as a valuable tool for studying the cell biology of gliomas and are established as a model for human glioblastoma. Their significance lies in their ability to provide insights into various aspects of cellular physiology and chemosensitivity related to gliomas. They offer a platform to evaluate potential therapies, including radiation, for human gliomas, aiding in the development and testing of novel treatment strategies for this aggressive form of brain cancer.