For research use only
| Cat No. | ABC-TC1017 |
| Product Type | Human Nerve Tumors Cell Lines |
| Cell Type | Fibroblast-like |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Brain |
| Product Code | SF-126; SF 126 |
SF-126 glioblastoma cells show fibroblast-like morphology, aneuploidy, lack GFAP due to hypermethylation, and form tumors intracranially in mice.
The SF-126 cell line is a human glioblastoma model originally isolated from a 50-year-old female patient’s astrocytoma tissue in the left frontal lobe. These tumor cells exhibit fibroblast-like morphology with adherent growth properties. Karyotype analysis reveals aneuploidy with chromosome counts ranging from 43 to 47, indicative of genomic instability characteristic of aggressive gliomas . SF-126 lacks glial fibrillary acidic protein (GFAP) expression due to promoter hypermethylation, a feature associated with high-grade astrocytomas. The cells demonstrate tumorigenic potential in xenograft models, with studies showing intracranial tumor formation in immunocompromised mice.
| Product Code | SF-126; SF 126 |
| Species | Human |
| Cat.No | ABC-TC1017 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Fibroblast-like |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Brain |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Nerve Tumors Cell Lines |
SF126 cells serve as a valuable tool for studying the cell biology of gliomas and are established as a model for human glioblastoma. Their significance lies in their ability to provide insights into various aspects of cellular physiology and chemosensitivity related to gliomas. They offer a platform to evaluate potential therapies, including radiation, for human gliomas, aiding in the development and testing of novel treatment strategies for this aggressive form of brain cancer.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
