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| Product Code | SK N SH; SKN-SH; SK-NSH; SKNSH; NSH |
| Species | Human |
| Cat.No | ABC-TC1049 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Bone Marrow |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Nerve Tumors Cell Lines |
SK-N-SH is a human neuroblastoma cell line that was originally isolated from metastatic cells found in a 4-year-old female patient’s bone marrow aspirate. SK-N-SH exhibits epithelial-like morphology and adherent culture properties. The stemline karyotype model number of SK-N-SH is 47, with normal chromosomes N9 and N22 being monosomic, and N7 being trisomic. Structural changes form two marker chromosomes, 9q+ and 22q+, with an additional band on one copy of chromosome N7, forming the marker chromosomes described by R.C. Seeger. These cells may have partial translocations on the q arms of chromosomes N9 and N22.
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The SK-N-SH cell line is a widely used model in neuroscience research. It facilitates studies on neuronal differentiation, neurodevelopment, and signal transduction. Researchers use these cells to explore the mechanisms of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, and to evaluate neurotoxicity and neuroprotective agents. Their ability to differentiate into neuron-like cells also supports research into brain development and neurological drug discovery.
