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C57BL/6 Mouse Neurons-substantia nigra

Product Name

C57BL/6 Mouse Neurons-substantia nigra

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Cat.No

ABC-TC032L

Species

C57BL/6 Mouse

Cell Type

Neuron

Growth Mode

Adherent

Size/Quantity

1 vial

Biosafety Level

1

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

Neurons are the functional units of the brain. Substantia nigra are isolated from C57BL/6 mouse neurons at embryonic day 18. AcceGen develop a simple, new, and reproducible method to isolate substantia nigra from C57BL/6 mouse neurons. Each vial contains at least 1×10^6 cells per ml.

Disease

Normal

Source Organ

Brain

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Recommended Medium And Supplement
Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

For research use only

Growth Conditions

37 ℃, 5% CO2

QuestionsthreeMorphology of C57BL/6 Mouse Neurons-substantia nigra
Product Type

Mouse Cells

Product Image AcceGen Frozen Cells & Cell Lines 1 vial

Frequently Asked Questions

  • What is C57BL/6 Mouse Neurons-substantia nigra?

    The central nervous system is composed of neurons and glia. Neurons, which act as the anatomic, functional, and trophic units, are dynamically polarized to transmit electrochemical signals. Despite their diverse sizes and shapes, neurons possess essential morphological features critical for complex communication. The substantia nigra, a midbrain cluster of dopaminergic neurons, is involved in learning, addiction, and movement. Dysfunction or loss of neurons-substantia nigra is linked to disorders such as drug addiction, schizophrenia, and Parkinson’s disease.

  • Application of C57BL/6 Mouse Neurons-substantia nigra

    C57BL/6 Mouse Neurons-substantia nigra are essential in experimental research for studying Parkinson’s disease, drug addiction, and schizophrenia. These neurons provide a reliable model to investigate the pathophysiology of dopaminergic neuron degeneration and dysfunction. Additionally, they are crucial for understanding the mechanisms of synaptic plasticity, neurotransmitter release, and receptor signaling pathways in the substantia nigra, contributing to the development of targeted treatments for various neurodegenerative and psychiatric disorders.

  • Morphology of C57BL/6 Mouse Neurons-substantia nigra

    When culturing C57BL/6 mouse substantia nigra neurons in vitro, they undergo significant morphological changes. In the initial phase (0-3 days), neurons appear round, gradually adhere to the substrate, and extend short neurites. In the intermediate phase (4-7 days), neurites lengthen and branch, forming preliminary dendritic and axonal networks with developing synaptic connections. In the mature phase (8-14 days and beyond), neurons form complex neural networks, further extending and branching dendrites and axons, with increased synaptic connections and displaying dopaminergic characteristics such as dopamine synthesis and release. During culture, ensure sterile techniques, timely medium changes, constant temperature and gas environment (37oC, 5% CO2), and control cell density to prevent overcrowding or sparse growth.

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