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Primary Cells

C57BL/6 Mouse Astrocytes-Brain

  • For research use only

Cat No.

ABC-TC033L
Product Type

Mouse Cells
Cell Type

Astrocyte
Species

C57BL/6 Mouse
Growth Conditions

37 ℃, 5% CO2
Source Organ

Brain
Disease

Normal
Storage

Liquid Nitrogen

C57BL/6 mouse astrocytes have star-shaped morphology,support neuronal homeostasis, maintain BBB while modulating neuroinflammation and synaptic activity.

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  • C57BL/6 Mouse Astrocytes-Brain
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Home | Primary Cells | Animal Primary Cells | Mouse Primary cells | C57BL/6 Mouse Astrocytes-Brain

Description

C57BL/6 Mouse Astrocytes are primary glial cells isolated from the cerebral cortex or hippocampus of C57BL/6 mice, an inbred strain widely used in neurological research. These star-shaped cells play essential roles in central nervous system homeostasis, including neurotransmitter recycling (particularly glutamate via GLT-1/GLAST transporters), metabolic support to neurons through the lactate shuttle, and maintenance of the blood-brain barrier. In pathological conditions, astrocytes undergo reactive gliosis, characterized by hypertrophy, increased GFAP expression, and altered cytokine secretion (e.g., elevated TNF-α, IL-1β). The C57BL/6 genetic background makes these astrocytes particularly valuable for modeling neuroinflammatory diseases, neurodegenerative disorders, and ischemic stroke, as this strain exhibits consistent disease susceptibility and well-characterized inflammatory responses.

Product Code

C57BL/6 Mouse Astrocytes-Brain, C57BL/6 Brain Astrocytes, Mouse Cerebral Astrocytes C57BL/6, CNS Astroglia C57BL/6, Brain Astrocytes Mouse
Species

C57BL/6 Mouse
Cat.No

ABC-TC033L
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Astrocyte
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Brain
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Mouse Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • C57BL/6 mouse astrocytes serve as a valuable model for studying neuroinflammation, neurodegenerative diseases, and CNS injury responses. These cells can be used to investigate astrocyte-mediated mechanisms in conditions such as Alzheimer’s disease, multiple sclerosis, and stroke, including their roles in synaptic regulation, blood-brain barrier maintenance, and cytokine secretion. Additionally, C57BL/6 mouse astrocytes are widely employed for drug screening, particularly for testing neuroprotective compounds, anti-inflammatory agents, and modulators of glial activation. Their genetic consistency and relevance to human disease pathways make them a reliable tool for both basic and translational neuroscience research.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Frequently Asked Questions

  • What are C57BL/6 Mouse Astrocytes?

    C57BL/6 Mouse Astrocytes are a type of glial cell found in the central nervous system (CNS) of C57BL/6 mice. They provide support and maintenance to neurons, regulate the extracellular environment, and contribute to various neurological functions.

  • What research areas are C57BL/6 Mouse Astrocytes used in?

    These cells are employed in a wide range of research areas related to neuroscience, including neurodevelopment, neurodegenerative diseases (e.g., Alzheimer’s disease, Parkinson’s disease), neuroinflammation, glioma biology, traumatic brain injury, and drug discovery targeting CNS disorders.

  • What are the advantages of using C57BL/6 Mouse Astrocytes in research?

    Using C57BL/6 Mouse Astrocytes provides a genetically tractable and reproducible model system for studying astrocyte biology and their contributions to CNS function and dysfunction. Their use allows researchers to investigate specific genetic factors, signaling pathways, and cellular interactions relevant to neurological health and disease.

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