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Product Code | HeLa s3; HeLa-S3; HELA-S3; HeLa/S3; HeLa.S3; HeLa S 3; HeLa S-3; HeLaS3; HeLa, S3 clone; S3-HeLa; S3 HeLa |
Species | Human |
Cat.No | ABC-TC0358 |
Product Category | Tumor Cell Lines |
Size/Quantity | 1 vial |
Cell Type | Epithelial |
Shipping Info | Dry Ice |
Growth Conditions | 37 ℃, 5% CO2 |
Source Organ | Cervix |
Disease | Cervix Cancer |
Biosafety Level | 1 |
Storage | Liquid Nitrogen |
Product Type | Human Uterine Cancer Cell Lines |
HeLa S3 is a subline of original HeLa cervical adenocarcinoma cell line, first established in 1951 from the cervical tumor of a 31-year-old African American female patient. This subline has been adapted for suspension culture while displaying an epithelial-like morphology. The karyotype is highly aneuploid, with a modal chromosome number of 68. HeLa S3 retains the tumorigenic potential of its parental line. HeLa S3 cells contain integrated sequences of human papilloma virus 18 (HPV-18), with multiple proviral insertions throughout the genome. They are frequently utilized in research focusing on chromosomal abnormalities, cell cycle regulation, and cytotoxicity. Their adaptability to suspension culture makes them especially suitable for large-scale biochemical and pharmaceutical assays.
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HELA S3 cells are extensively used in a variety of research areas, including cytogenetics, virology, and oncology. They serve as a robust model for studying chromosomal variation, nutritional requirements of mammalian cells, and clonal growth behavior. Their utility in plaque-forming assays and viral replication studies has also contributed significantly to the advancement of cell biology and genetic research. The HeLa S3 subline’s suspension-culture adaptability and genetic stability make it a preferred choice for high-throughput drug screening and cellular response analyses, particularly in evaluating cytotoxicity and genetic expression in human cancer cells.