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Home > Products > Human Tumor Cell Lines >

MES-SA/Dx-5

ImageAcceGen cells & cell lines
Product Name

MES-SA/Dx-5

Cat.No

ABC-TC5562

Product Type

Human Uterine Cancer Cell Lines

Species

Human

Size/Quantity

1 vial

Shipping Info

Dry ice

Storage

Liquid Nitrogen

Description

The multi drug-resistant cell line MES-SA/Dx5 was derived from the human uterine sarcoma cell line MES-SA which was originally obtained from a tumour from a 56-year-old Caucasian female at the time of hysterectomy. The Dx5 variant exhibits a 100-fold resistance to Adriamycin and has a reported doubling time of 30 hours. The two additional marker chromosomes indicate clonal selection during drug selection. MES-SA/Dx-5 cells exhibit marked cross-resistance to a number of chemotherapeutic agents (including daunorubicin, dactinomycin, vincristine, taxol, colchicine) and moderate cross-resistance to MMC and melphalan.

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Application

For research use only

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