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Primary Cells

Human Choroid Plexus Endothelial Cells

  • For research use only

Cat No.

ABC-TC3567
Product Type

Nervous Cells
Cell Type

Endothelial
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Choroid Plexus
Disease

Normal
Storage

Liquid Nitrogen

Human choroid plexus endothelial cells express PECAM1, tight junctions, form capillaries; limited growth, cryopreserved, avoid freeze-thaw.

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Home | Primary Cells | Human Primary Cells | Nervous System Primary Cells | Human Choroid Plexus Endothelial Cells

Description

Human Choroid Plexus Endothelial Cells (HCPEnC) are primary cells isolated from healthy human brain tissue and cryopreserved following initial culture. These endothelial cells exhibit typical cobblestone morphology and form capillary-like tubular structures in vitro, reflecting key aspects of human choroid plexus function within the neurovascular system. Immunofluorescence analysis confirms the expression of endothelial markers including PECAM1 (CD31), VE-cadherin, and von Willebrand factor (vWF). In addition, HCPEnCs express tight junction proteins such as ZO-1, occludin (OCLN), claudin-1 (CLDN1), and claudin-5 (CLDN5), which are critical for regulating choroid plexus endothelial permeability, maintaining blood–cerebrospinal fluid barrier integrity, and controlling immune cell trafficking. Owing to these specialized barrier properties, HCPEnCs serve as a robust in vitro model for neurovascular research, supporting a wide range of CPEC research applications, including studies of blood–cerebrospinal fluid barrier function, neuroinflammation, multiple sclerosis, brain tumors, and other CNS-related conditions. Under appropriate CPEC culture conditions, these cells display limited proliferative capacity and are non-passagable in vitro. To preserve their viability and functional properties, repeated freeze–thaw cycles should be avoided.

Product Code

Human Choroid Plexus Endothelial Cells, Choroid Plexus ECs Human, CP Endothelial Cells, Human Ventricular Endothelial Cells, HCP-ECs
Species

Human
Cat.No

ABC-TC3567
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Endothelial
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Choroid Plexus
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Nervous Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Choroid Plexus Endothelial Cells are used to model the blood-cerebrospinal fluid barrier in vitro, enabling studies of CNS drug delivery, immune cell transmigration, and vascular inflammation. They support research on neurovascular unit function, blood-brain barrier disruption, and pathological mechanisms underlying neurodegenerative diseases and brain tumors. These cells are also valuable in high-throughput screening for therapies targeting CNS vascular disorders and inflammatory processes.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Frequently Asked Questions

  • What are Human Choroid Plexus Endothelial Cells?

    Human Choroid Plexus Endothelial Cells are specialized cells lining the blood vessels within the choroid plexus, which plays a critical role in regulating the passage of molecules between the bloodstream and the cerebrospinal fluid (CSF), contributing to brain homeostasis and immune surveillance.

  • How do Human Choroid Plexus Endothelial Cells contribute to the blood-CSF barrier?

    These endothelial cells, together with tight junctions and the surrounding epithelial cells, form part of the blood-CSF barrier. This barrier tightly controls the movement of ions, molecules, and cells between the blood and the cerebrospinal fluid, maintaining a selective permeability crucial for brain health.

  • What makes the permeability of Human Choroid Plexus Endothelial Cells unique?

    Unlike endothelial cells in other parts of the body, Choroid Plexus Endothelial Cells possess unique transporters and low permeability, which ensures the controlled exchange of solutes while preventing harmful substances from entering the cerebrospinal fluid. This specialized permeability is essential for regulating brain fluid dynamics.

  • How are Human Choroid Plexus Endothelial Cells isolated?

    These cells are isolated from the vasculature of the choroid plexus in human brain tissue. Isolation involves precise dissection, followed by enzyme digestion and purification, to obtain a pure population of endothelial cells for in vitro studies.

  • What are the potential applications of Human Choroid Plexus Endothelial Cells in drug discovery?

    These cells are used in drug discovery to screen for compounds that can cross the blood-CSF barrier or modulate its function. They provide a platform for testing drugs aimed at treating neurodegenerative diseases, neuroinflammatory disorders, and conditions affecting cerebrospinal fluid dynamics.

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