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Primary Cells

Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis, Adult

  • For research use only

Cat No.

ABC-TC3621
Product Type

Synoviocytes
Cell Type

Fibroblast-Like
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

synovium
Disease

Normal
Storage

Liquid Nitrogen

Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis, Adult supports RA pathogenesis studies, joint inflammation modeling, and drug response profiling.

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  • Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis, Adult
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Home | Primary Cells | Human Primary Cells | Motion System Primary Cells | Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis, Adult

Description

Human Fibroblast-Like Synoviocyte (HFLS) Rheumatoid Arthritis, Adult are primary cells derived from adult rheumatoid arthritis (RA) synovial tissue, exhibiting the aggressive phenotype characteristic of this autoimmune disease. They are cryopreserved at an early passage. These cells demonstrate hallmark morphological changes including increased size and irregular shape, with elevated expression of activation markers (CD55, VCAM-1, cadherin-11) and matrix-degrading enzymes. The RA-FLS display pathogenic behaviors such as anchorage-independent growth and enhanced migration/invasion capacity, driven by upregulated Wnt and NF-κB signaling pathways. Disease-specific gene expression profiles include overexpression of IL-6, IL-8, RANKL, and prostaglandin synthases. They are widely used to study RA pathogenesis and anti-inflammatory drug screening.

Product Code

Human Adult Rheumatoid Arthritis Fibroblast-Like Synoviocytes, RA FLS Adult, Rheumatoid Synovial Fibroblasts, HFLS-RA, Synoviocytes Rheumatoid Arthritis
Species

Human
Cat.No

ABC-TC3621
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Fibroblast-Like
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

synovium
Disease

Normal
Storage

Liquid Nitrogen
Product Type

Synoviocytes
Key Features

– Backed by AcceGen advanced technology

– Cryopreserved for highest viability and plating efficiency

– Quality-guaranteed for accurate results

– Timely technical support for best experimental outcomes
Quality Control

All cell lots test negative for HIV-1, HBV, HCV, mycoplasma, yeast, fungi, and other pathogens.

Application

  • Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis (HFLS-RA) serve as a useful tool for understanding the etiology and pathogenesis of RA. They can be used to establish cellular models to study key cytokine production that contributes to RA, explore the molecular signaling pathways implicated in the development of joint inflammation, or to evaluate anti-inflammatory compounds and identify potential drug targets.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Frequently Asked Questions

  • What are Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis?

    Human Fibroblast-Like Synoviocytes are cells found in the synovial membrane of joints affected by Rheumatoid Arthritis. They play a key role in the pathogenesis of Rheumatoid Arthritis by contributing to inflammation, joint destruction, and the production of cytokines and matrix metalloproteinases.

  • What research areas are Human Fibroblast-Like Synoviocyte from Rheumatoid Arthritis patients used in?

    Human Fibroblast-Like Synoviocyte from Rheumatoid Arthritis patients are utilized in various research areas, including elucidating the molecular mechanisms underlying Rheumatoid Arthritis pathogenesis, identifying potential therapeutic targets, and screening anti-inflammatory or disease-modifying drugs.

  • Advantages of using Human Fibroblast-Like Synoviocyte from Rheumatoid Arthritis patients

    Using Human Fibroblast-Like Synoviocyte from Rheumatoid Arthritis patients provides a clinically relevant model system for studying the pathophysiology of Rheumatoid Arthritis. These cells retain disease-specific characteristics and can be used to investigate patient-specific responses to treatments, facilitating the development of personalized therapies for Rheumatoid Arthritis.

  • How many cells are in a vial of Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis, Adult?

    Each vial contains more than 0.5 million cells.

  • Where does human fibroblast come from?

    Human fibroblasts originate from mesenchymal cells within connective tissues throughout the body. In synovial tissue, fibroblast-like synoviocytes are derived from the joint lining and play key roles in extracellular matrix production and joint homeostasis.

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