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Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis, Adult

Product Name

Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis, Adult

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Product Code

HFLS

Cat.No

ABC-TC3621

Species

Human

Size/Quantity

1 vial

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

Human Fibroblast-Like Synoviocytes (HFLS), also known as synovial fibroblasts, are the predominant cell types consisting of synovial intima. Two major cell populations of synoviocytes, macrophage-like (type A) synoviocytes and fibroblast-like (type B) synoviocytes, have been identified. Abnormal fibroblast-like synoviocytes (FLS) activity is closely associated with the occurrence and progression of rheumatoid arthritis (RA), a chronic disorder marked by inflammation in the synovium. Rheumatoid arthritis FLS exhibit aggressive phenotypes and produce cytokines and proteases that perpetuate inflammation and eventually contribute to cartilage destruction. Research and therapeutic strategies targeting FLS could provide novel insight into RA diagnosis and treatment.

Why choose HFLS-RA from AcceGen?

HFLS-RA is isolated from adult joint synovial tissue with RA using AcceGen’s advanced technology. Cells at second passage are cryopreserved to ensure the best viability. Each vial contains more than 5×10^5 cells in 1ml volume. HFLS-RA is characterized by fibroblast-like morphology and the expression of fibronectin using immunofluorescence. HFLS-RA is guaranteed for further expansion of at least 5 doublings following protocols provided by AcceGen.

Disease

Normal

Source Organ

synovium

Quality Control

All cell lots test negative for HIV-1, HBV, HCV, mycoplasma, yeast, fungi, and other pathogens.

Recommended Medium And Supplement
Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

For research use only

Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis (HFLS-RA) serves as a useful tool for understanding the etiology and pathogenesis of RA. They can be used to establish cellular models to study key cytokine production that contributes to RA, to explore the molecular signaling pathways implicated in the development of joint inflammation, or to evaluate anti-inflammatory molecules and identify potential drug targets.

Key Features

– Backed by AcceGen advanced technology

– Cryopreserved for highest viability and plating efficiency

– Quality-guaranteed for accurate results

– Timely technical support for best experimental outcomes

Growth Conditions

37 ℃, 5% CO2

Cell Type

Fibroblast-Like

Growth Mode

Adherent

QuestionsthreeAdvantages of using Human Fibroblast-Like Synoviocyte from Rheumatoid Arthritis patients
Product Type

Synoviocytes

Product Image AcceGen Frozen Cells & Cell Lines 1 vial

Related Resources

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Frequently Asked Questions

  • What are Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis?

    Human Fibroblast-Like Synoviocytes are cells found in the synovial membrane of joints affected by Rheumatoid Arthritis. They play a key role in the pathogenesis of Rheumatoid Arthritis by contributing to inflammation, joint destruction, and the production of cytokines and matrix metalloproteinases.

  • What research areas are Human Fibroblast-Like Synoviocyte from Rheumatoid Arthritis patients used in?

    Human Fibroblast-Like Synoviocyte from Rheumatoid Arthritis patients are utilized in various research areas, including elucidating the molecular mechanisms underlying Rheumatoid Arthritis pathogenesis, identifying potential therapeutic targets, and screening anti-inflammatory or disease-modifying drugs.

  • Advantages of using Human Fibroblast-Like Synoviocyte from Rheumatoid Arthritis patients

    Using Human Fibroblast-Like Synoviocyte from Rheumatoid Arthritis patients provides a clinically relevant model system for studying the pathophysiology of Rheumatoid Arthritis. These cells retain disease-specific characteristics and can be used to investigate patient-specific responses to treatments, facilitating the development of personalized therapies for Rheumatoid Arthritis.

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