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Human Fibroblast-Like Synoviocyte Osteo Arthritis, Adult

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Human Fibroblast-Like Synoviocyte Osteo Arthritis, Adult

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1 vial

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Dry Ice


Liquid Nitrogen


Human Fibroblast-Like Synoviocytes (Osteoarthritis, Adult), are isolated from the synovial tissue of donors with osteoarthritis. Human fibroblast-like synoviocytes (FLS), also known as synovial fibroblasts, are vital constituents of the synovial membrane lining the inner layer of joint capsules. These cells play a pivotal role in maintaining normal joint function by generating extracellular matrix components and lubricants. However, in conditions like rheumatoid arthritis (RA), FLS can undergo proliferation and phenotypical alterations, transforming into key contributors to inflammation persistence through their direct and indirect destructive actions, thus exacerbating joint damage and dysfunction.


Why choose Human Fibroblast-Like Synoviocyte-Osteoarthritis, Adult from AcceGen?

The Human Fibroblast-Like Synoviocyte-Osteoarthritis, Adult cells from AcceGen are cryopreserved at the 2nd passage, with each vial containing more than 0.5×106 cells. These cells have the capacity to undergo at least 5 doublings in culture and are provided in a sterile state, free from bacteria, yeast, fungi, mycoplasma, and viruses, ensuring their suitability for research and experimentation.



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Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

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Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).



Human Fibroblast-Like Synoviocyte-Osteoarthritis, Adult, referred to as HFLS-OA, serve as valuable tools in diverse research applications. They are instrumental in probing synoviocyte physiology, shedding light on their role in both the development and treatment of osteoarthritis. HFLS-OA cells are utilized to investigate various aspects such as phenotype, proinflammatory mediator production, signaling pathways, cell proliferation, and chemotaxis. Moreover, when combined with normal FLS (HFLS)  and rheumatoid arthritis-FLS (HFLS-RA) , they aid in studying interleukin production, evaluating potential anti-inflammatory and antirheumatic compounds, as well as assessing the production of erosive enzymes, providing critical insights into the complexities of osteoarthritis and potential therapeutic avenues.

Growth Conditions

37 ℃, 5% CO2

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Growth Mode


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Product Image AcceGen Frozen Cells & Cell Lines 1 vial
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