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Primary Cells

Human Osteoclast Precursor Cells

  • For research use only

Cat No.

ABC-H0014X
Product Type

Blood Products
Cell Type

Osteoclast
Species

Human
Growth Conditions

37 ℃, 5% CO2
Disease

Normal
Storage

Liquid Nitrogen

Human Osteoclast Precursor Cells are cryopreserved, TRAP-positive, and support osteoclast differentiation studies for bone and resorption research.

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  • Human Osteoclast Precursor Cells
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Home | Primary Cells | Human Primary Cells | Blood System Primary Cells | Human Osteoclast Precursor Cells

Description

Human Osteoclast Precursor Cells (OCPs) are primary mononuclear cells derived from peripheral blood, bone marrow, or umbilical cord blood of healthy human donors. These cells are precursors to multinucleated osteoclasts and are implicated in bone-resorptive diseases such as osteoporosis, rheumatoid arthritis, and multiple myeloma. Following isolation, they are cryopreserved and typically not passaged due to their limited proliferative capacity. These cells represent an early stage in the osteoclast lineage and exhibit a round or slightly irregular morphology. Functionally, These precursors express markers such as CD11b, CD14, CD115, tartrate-resistant acid phosphatase (TRAP), cathepsin K, RANK, and NFATc1, with CD16⁺ subsets showing heightened osteoclastogenic potential in inflammatory conditions. Their differentiation is RANKL-dependent, making them powerful models for studying bone metabolism disorders.

Product Code

Human Osteoclast Precursor Cells, Osteoclast Progenitors, hOCPs, Monocyte Derived Osteoclast Precursors, Pre-Osteoclasts
Species

Human
Cat.No

ABC-H0014X
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Osteoclast
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Blood Products
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Osteoclast Precursor Cells (OCPs) have versatile applications, particularly in high-throughput studies focused on osteoporosis, bone resorption, and related disorders. They provide valuable insights into how environmental factors affect osteoclast formation and contribute to disease pathogenesis. Additionally, these cells enable detailed investigation of key regulators—such as chemokines and macrophage colony-stimulating factor (M-CSF)—that influence the recruitment of osteoclast precursors to bone tissue. Improved understanding of OCP heterogeneity, behavior, and recruitment mechanisms offers promising avenues for developing targeted therapies aimed specifically at osteoclast-related conditions.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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