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Primary Cells

Human Pancreatic Fibroblasts

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Human Primary Pancreatic Fibroblasts are isolated from normal human pancreatic tissue. Human Primary Pancreatic Fibroblasts are grown in T75 tissue culture flasks pre-coated with gelatin-based coating solution for 2 min and incubated in AcceGen’s Culture Complete Growth Medium generally for 3-7 days. Cultures are then expanded. Prior to shipping, cells at passage 1 are detached […]
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Home | Primary Cells | Human Primary Cells | Endocrine System Primary Cells | Human Pancreatic Fibroblasts
Species

Human
Cat.No

ABC-TC5470
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Fibroblast
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Pancreas
Disease

Normal
Storage

Liquid Nitrogen
Product Type

Pancreatic Cells
Key Features

-Backed by AcceGen advanced technology
-Cryopreserved for highest viability and plating efficiency
-Quality-tested for accurate results

Description

Human Pancreatic Fibroblasts are derived from human pancreatic tissue. As mesenchymal cells, they predominantly localize in the periacinar, perivascular, and periductal regions of the pancreas, playing essential roles in wound healing and tissue homeostasis. Morphologically, these cells exhibit a characteristic elongated fusiform or spindle-shaped appearance. Functionally, they secrete extracellular matrix (ECM) components, including collagen, fibronectin, and elastin, thereby maintaining the structural integrity of pancreatic tissue. Additionally, they actively participate in ECM remodeling and turnover, particularly during pancreatic injury responses such as acute or chronic pancreatitis. In vitro, these cells exhibit adherent growth. They are non-tumorigenic and retain a stable karyotype under normal culture conditions. Human Pancreatic Fibroblasts may also influence local immune responses through the secretion of cytokines and chemokines under inflammatory conditions.

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

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Application

  • Human pancreatic fibroblasts can be used as an in vitro cell model to study the heterogeneity of pancreatic fibroblast populations, as wells as their potential role in pancreatic injury and pancreatic cancer. They can also be used to investigate the origin and molecular characteristics of pancreatic cancer-associated fibroblasts.

Frequently Asked Questions

  • What are Human Pancreatic Fibroblasts?

    Human pancreatic fibroblasts are specialized cells located in the pancreas that provide structural support and produce extracellular matrix components. They play a crucial role in maintaining the tissue architecture and function of the pancreas.

  • What is the primary function of pancreatic fibroblasts?

    The primary function of pancreatic fibroblasts is to synthesize and remodel the extracellular matrix, support pancreatic tissue structure, and facilitate tissue repair and regeneration. They also play a role in modulating inflammation and fibrosis.

  • How do pancreatic fibroblasts affect the tumor microenvironment?

    In the tumor microenvironment, pancreatic fibroblasts (often referred to as cancer-associated fibroblasts, or CAFs) secrete growth factors, cytokines, and extracellular matrix components that support tumor cell survival, proliferation, and invasion. They also contribute to the development of a fibrotic stroma that can impede drug delivery.

  • What are the therapeutic uses of targeting pancreatic fibroblasts?

    Therapeutic applications include developing drugs that target fibroblast activity to reduce fibrosis and improve pancreatic function in diseases like chronic pancreatitis. In pancreatic cancer, targeting fibroblasts and their interactions with cancer cells could enhance the effectiveness of cancer treatments and inhibit tumor progression.

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