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Human Pancreatic Stellate Cells

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Pancreatic Stellate Cells (HPaSteC) are the main fibroblastic cells of the pancreas. HPaSteC are responsible for the synthesis and the degradation of the extracellular matrix proteins that promote tissue repair. They are found adjacent to pancreatic acinar cells and around small pancreatic ducts and blood vessels. When pancreatic stellate cells are activated, they assume myofibroblast-like […]
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Home | Primary Cells | Human Primary Cells | Endocrine System Primary Cells | Human Pancreatic Stellate Cells
Product Code

HPaSteC
Species

Human
Cat.No

ABC-TC3746
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Stellate Cell
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Pancreas
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Pancreatic Cells
Key Features

-Backed by AcceGen advanced technology
-Cryopreserved for highest viability and plating efficiency
-Quality-tested for accurate results

Description

Human Pancreatic Stellate Cells (PSCs) are isolated from human pancreatic tissue and play an important role in desmoplastic reaction associated with pancreas diseases.Morphologically, PSCs display a star-like shape with cytoplasmic processes and exhibit a quiescent or activated phenotype depending on the microenvironment. PSCs are subject to regulation by both autocrine and paracrine factors. They share a multitude of characteristics with their hepatic counterparts. In a resting state, it synthesizes and secretes a small amount of ECM components, such as collagen, fibronectin, laminin, to maintain the normal structure and function of pancreatic tissue. Upon pancreatic injury or inflammation, PSCs become activated, markedly upregulating ECM synthesis and secretion, thereby driving pancreatic fibrosis—a key pathological feature in chronic pancreatitis and pancreatic cancer progression.

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Application

  • Human Pancreatic Stellate Cells (PSCs) can be used as an in vitro cell model to explore the tumor-stroma interaction mechanism in the pancreatic cancer microenvironment and test the efficacy of anti-fibrotic drugs. Its co-culture system with pancreatic cancer cells can simulate the tumor-promoting desmoplastic response, providing an important platform for studying chemotherapy resistance.

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