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Tumor Cell Lines

MIN-6

  • 672
Insulinoma (Radiation induced cell immortalization).
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Product Code

Min6; MIN-6; Mouse INsulinoma 6

Species

Mouse

Cat.No

ABC-TC234S

Product Category Tumor Cell Lines
Size/Quantity

1 vial

Cell Type

β Cell

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Source Organ

Pancreas

Storage

Liquid Nitrogen

Product Type

Mouse Pancreas Cancer Cell Lines

Description

MIN-6
MIN-6 is a murine β-cell line derived from C57BL/6 background IT6 transgenic mice. Although not from diabetic models, MIN-6 is used in β-cell regulation, islet development, and diabetes-related studies. These cells exhibit glucose-dependent insulin secretion like normal mouse islet cells but are a mixed cell line, secreting insulin, glucagon, somatostatin, and ghrelin. They display polygonal morphology and grow as monolayers under standard conditions (37°C, 5% CO₂) with a doubling time of 2–3 days. They express insulin I & II, liver-type glucose transporter mRNA, proglucagon, somatostatin, pancreatic polypeptide (PP), and ghrelin mRNA.When transplanted into immunocompromised mice, MIN-6 cells form tumors and secrete insulin, demonstrating tumorigenic potential. They are free of HPV, HIV, or EBV. MIN-6 is an important model in β-cell function, cytokine signaling, oncogene activity, and drug screening.
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Citation

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Application

  • Due to its glucose-responsive insulin secretion capability, the MIN-6 cell line is widely used to study beta cell regulatory mechanisms. It serves as a valuable model for investigating pancreatic islet development, cell differentiation, and overall islet function. Researchers can utilize MIN-6 cells to gain insights into the intricate processes involved in insulin secretion and explore potential therapeutic strategies for beta cell-related disorders, particularly diabetes.

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