For research use only
| Cat No. | ABC-TC234S |
| Product Type | Mouse Pancreas Cancer Cell Lines |
| Cell Type | β Cell |
| Species | Mouse |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Pancreas |
| Product Code | Min6; MIN-6; Mouse INsulinoma 6 |
MIN-6 cells are valuable for diabetes research, supporting insulin secretion and beta-cell function studies to advance metabolic disease understanding. MIN-6 cell line is currently unavailable. We highly recommend Beta-TC-6 (Cat.No. ABC-TC0074) as an established alternative for glucose-stimulated insulin secretion studies.
MIN-6 is a murine β-cell line derived from a transgenic mouse insulinoma, established by expressing the SV40 T-Ag under the control of the insulin gene promotor (C57BL/6 background). These adherent cells exhibit polygonal morphology and maintain glucose-stimulated insulin secretion (GSIS), closely mimicking the behavior of normal pancreatic β-cells. Although not from diabetic models, MIN-6 is used in β-cell regulation, islet development, and diabetes-related studies. MIN6 cells express key β-cell markers including insulin I & II, liver-type glucose transporter mRNA, proglucagon, somatostatin, pancreatic polypeptide (PP), and ghrelin mRNA. They possess a near-diploid karyotype with some chromosomal abnormalities due to immortalization. When transplanted into immunocompromised mice, MIN-6 cells form tumors and secrete insulin, demonstrating tumorigenic potential. They are widely recognized for preserving functional characteristics of primary islets, including regulated insulin production in response to glucose and other secretagogues.
| Product Code | Min6; MIN-6; Mouse INsulinoma 6 |
| Species | Mouse |
| Cat.No | ABC-TC234S |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | β Cell |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Pancreas |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Mouse Pancreas Cancer Cell Lines |
The MIN-6 cell line, characterized by glucose-responsive insulin secretion, is widely used to study beta cell regulation. It serves as a key model for pancreatic islet development, differentiation, and function, enabling investigation of insulin secretion mechanisms. MIN-6 cells support research into therapeutic strategies for beta cell dysfunction and diabetes.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
The recommended medium for MIN-6 cells is RPMI-1640 supplemented with 20% FBS, 0.05 mM 2-mercaptoethanol, and 1% Penicillin-Streptomycin (PS).
We recommend that the passage number of MIN-6 cells should not exceed 35 generations. Within the range of 10-35 passages, the cells maintain good insulin secretion functionality and morphology. However, passing beyond 35 generations may lead to genetic mutations, functional decline, and a reduction in insulin secretion capacity.
