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| Product Code | alpha TC1 clone 9; alphaTC clone 9; alpha-TC1.9; alphaTC1.9; alpha-TC1-9; aTC1 Clone 9; aTC1-9 |
| Species | Mouse. (C57BL/6J X DBA/2)F2 (Transge |
| Cat.No | ABC-TC230S |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | α Cell |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Pancreas |
| Disease | Islet Cell Adenoma |
| Storage | Liquid Nitrogen |
| Product Type | Mouse Pancreas Cancer Cell Lines |
Alpha TC1-9 is a murine pancreatic alpha-cell model derived from an islet cell adenoma in transgenic mice (C57BL/6 × DBA/2 hybrids), immortalized using the SV40 large T antigen. These cells exhibit epithelial-like morphology and adherent growth properties. Cytogenetic analysis reveals aneuploidy, yet this line retains key alpha-cell functions, including glucagon secretion regulated by extracellular glucose concentrations. Alpha TC1-9 exhibits MHC heterozygosity reflective of its mixed parental background. Unlike its progenitor, Alpha TC1, this subclone does not express insulin or preproinsulin mRNA, making it a specific model for alpha-cell function without beta-cell interference. The cell line serves as a critical tool for studying alpha-cell physiology, chemical toxicity, and transdifferentiation mechanisms.
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The Alpha TC1-9 cell line offers a versatile platform for exploring multiple aspects of pancreatic alpha-cell biology. It facilitates detailed investigations of glucagon biosynthesis, biosynthesis, glucose sensing and cytokine responsiveness, contributing to a comprehensive understanding of the intricate regulation of glucose sensing and glucagon secretion. Furthermore, it plays a crucial role in elucidating the impacts of metabolism-disrupting chemicals on pancreatic endocrine function. Importantly, this cell line supports research into the transdifferentiation potential of alpha-cells into beta-cells, thus offering promising avenues for beta-cell regeneration and in diabetes research and therapeutic development.
