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| Product Code | PSN-1 |
| Species | Human |
| Cat.No | ABC-TC0915 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Pancreas |
| Disease | Adenocarinoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Pancreas Cancer Cell Lines |
PSN-1 is a human tumor cell line that was originally isolated from the pancreas of an age-unspecified male patient with pancreatic adenocarcinoma. PSN-1 exhibits epithelial-like morphology and adherent culture properties. It was established through transplantation into nude mice, originating from the xenograft. PSN1 cells maintain the same elevated levels of both c-myc (50-fold) and activated c-Ki-ras (3-6 fold) with a specific mutation (GGT to CGT at codon 12) as found in the original tumor. it is increased c-myc and c-Ki-ras transcripts are present. The cell line shows loss of one p53 allele and a mutation (AAG to CAG at codon 132) in the remaining allele.
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The PSN-1 cell line finds valuable application in the exploration of pancreatic cancer and the development of potential therapeutic interventions, including strategies such as chemoradiation treatment. This cell line’s significance lies in its representation of a cancer cell with intricate genetic alterations involving oncogenes (c-Ki-ras and c-myc) and a tumor suppressor gene (p53). Notably, PSN1 has been utilized for in vitro investigations, such as the study of synthetic acetylhomoagmatine, as well as for assessing the cytotoxicity of irinotecan and topotecan. These applications highlight PSN-1’s crucial role in advancing our understanding of pancreatic cancer and aiding the design of targeted treatment approaches.
