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QGP-1

Product Name

QGP-1

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Product Code

QGP 1; QGP1

Cat.No

ABC-TC0918

Species

Human

Size/Quantity

1 vial

Biosafety Level

1

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

QGP-1 is a neuroendocrine tumor cell line of pancreatic origin and can produce carcinoembryonic antigen (CEA). It originates from the neuroendocrine system in the pancreas, as confirmed by the expression of the neuronal marker, synaptophysin. The expression of transcription factors involving neuroendocrine cell differentiation in the pancreas was observed in QGP-1 cells.  Moreover, QGP-1 exhibited elevated gene expression levels related to immature or non-functional β/δ-cells genes, or pancreatic endocrine progenitors. QGP-1 is identified as G3 carcinomas by a Ki-67 (nuclear proliferation factor) labeling index of 82.6%±1.0%. When it was established in 1980, the doubling time of QGP-1 was about 84 hours (3.5 days), but this time was detected to be shorter, 38 hours, in 2018. With the use of these years, QGP-1 might become more malignant in culture. QGP-1 has the aberrant chromosome with a ploidy of 4.

 

Why choose QGP-1 from AcceGen?

AcceGen provides TE671 with numerous beneficial characteristics. We maintain strict sterility standards, ensuring the absence of bacterial, fungal, and mycoplasma contamination. Our exceptional cryopreservation techniques guarantee high cell viability, resulting in reliable experimental outcomes.

Source Organ

Pancreas

Recommended Medium And Supplement
Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
Si, Y., Kim, S., Guenter, R., Ou, J., Lu, Y., Chen, K., Zhang, J., Whitt, J., Carter, A.M., Bibb, J.A. and Jaskula-Sztul, R., 2019. Anti-SSTR2 Antibody-Drug Conjugate for Neuroendocrine Cancer Therapy. bioRxiv, p.688184.
Si, Y., Guan, J., Xu, Y., Chen, K., Kim, S., Zhou, L., Jaskula-Sztul, R. and Liu, X.M., 2020. Dual-Targeted Extracellular Vesicles to Facilitate Combined Therapies for Neuroendocrine Cancer Treatment. Pharmaceutics, 12(11), p.1079.
Herring, B., Jang, S., Whitt, J., Goliwas, K., Aburjania, Z., Dudeja, V., Ren, B., Berry, J., Bibb, J., Frost, A. and Chen, H., 2021. Ex Vivo Modeling of Human Neuroendocrine Tumors in Tissue Surrogates. Frontiers in endocrinology, 12.

Application

FOR RESEARCH USE ONLY

Panceras neuroendocrine tumors (panNET) are relatively rare pancreatic neoplasms, with an incidence of 0.43 per 100 000, and their clinical options are limited. However, the rates have increased rapidly in recent years, emphasizing the urgency to find novel therapies for panNET. QGP-1 can be useful as an in vitro model or in establishing a in vivo model for the drug development of neuroendocrine tumors (NET). QGP-1 is also a model of human enterochromaffin (EC) cells used to investigate the transient receptor potential ankyrin1 channel (TRPA1) due to a high expression of TRPA1 and EC cell marker genes.

Growth Conditions

37 ℃, 5% CO2

Cell Type

Epithelial-like

Product Type

Human Pancreas Cancer Cell Lines

Product Image

AcceGen Frozen Cells & Cell Lines

AcceGen product mpp-89 cell line

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