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Tumor Cell Lines

A-253

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The A253 line is one of thirteen to be isolated and partially characterized through trial studies on a series of 200 human tumors.
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Product Code

A 253; A253

Species

Human

Cat.No

ABC-TC0024

Product Category Tumor Cell Lines
Size/Quantity

1 vial

Cell Type

Epithelial

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Source Organ

Submaxillary Salivary Gland

Disease

Cancer

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Human Salivary Cancer Cell Lines

Description

A-253
A253 is a human salivary gland carcinoma cell line that was originally isolated from the submaxillary salivary gland. A253 exhibits epithelial-like morphology and adherent culture properties. This cell line is near triploid with at least 6 markers. It is one of thirteen series partially characterized by a comprehensive study involving 200 human tumors. A253 is tumorigenic.
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Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

  • A253 cells enable cancer research on tumor growth, metastasis, and drug resistance mechanisms while supporting HNSCC drug development through efficacy/toxicity testing. They facilitate cell signaling studies of growth/differentiation/apoptosis pathways and epigenetic research into cancer progression. These cells serve as in vitro models for assessing drug/chemical/radiation effects and studying cellular processes. Additionally, A253 cells advance new HNSCC therapies (e.g., anti-EGFR immunotoxins), evaluate drug resistance mechanisms, investigate cell communication (muscarinic/β-adrenergic receptors), probe tumor metabolism for therapeutic targeting, study laminin-mediated adhesion/differentiation, evaluate sonodynamic therapy’s apoptotic efficacy, and analyze calcium mobilization mechanisms.

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