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| Product Code | beta-TC-6; beta-TC6; beta TC6; BetaTC6; betaTC6 |
| Species | Mouse |
| Cat.No | ABC-TC0074 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Disease | Insulinoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Mouse Pancreas Cancer Cell Lines |
Beta-TC-6 is a murine pancreatic β-cell line derived from an insulinoma-formed in a transgenic mouse carrying a rat insulin II promoter-driven SV40 early gene pseudogene construct. These cells exhibit epithelial-like morphology and grow in adherent, island-like clusters. Beta-TC-6 retain key functional β-cell characteristics, including glucose-responsive insulin secretion and predominant insulin expression by Beta-TC-6 cells, alongside minor expression of glucagon and somatostatin. They express PDX1, a critical transcription factor for β-cell identity and insulin gene regulation. They harbor the SV40 large T antigen, contributing to their immortalized tumorigenic properties.
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The Beta-TC-6 cell line plays a pivotal role for studying pancreatic β-cell biology, particularly within the domains of diabetes mellitus and glucose metabolism. Its glucose-responsiveness and insulin-secretory capacity make it an invaluable tool for delving into the molecular mechanisms of insulin regulation, β-cell differentiation, and dysfunction in diabetic states. Beta-T-6 is widely used in screening anti-diabetic compounds, investigating islet cell gene expression, and evaluating the impact of genetic or pharmacological modulation on insulin pathways. Consequently, holds promise for studies in β-cell regeneration, islet transplantation, and novel diabetic therapeutic interventions.
