For research use only
| Cat No. | ABC-TC0091 |
| Product Type | Mouse Muscle Cell Lines |
| Cell Type | Myoblast |
| Species | Mouse |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Muscle |
| Disease | Normal |
| Product Code | C2c12; C2-C12; C12 |
C2C12 murine myoblasts differentiate into myotubes, express muscle markers, non-tumorigenic, ideal for muscle regeneration and differentiation studies.
C2C12 is a spontaneously immortalized murine myoblast cell line derived from the skeletal muscle of a 2-month-old female C3H mouse. In its undifferentiated state, C2C12 cells exhibit a bipolar spindle-shaped morphology. Upon differentiation, they fuse to form long, multinucleated myotubes expressing key myofilament proteins such as actin, myosin, and skeletal muscle troponin T (Tnnt3). C2C12 cells proliferate rapidly in high-serum conditions and undergo fusion under low-serum conditions to form functional myotubes, making them a widely used model for studying muscle differentiation and regeneration. The cell line does not exhibit tumorigenicity or metastatic potential in nude mice. C2C12 cells are resistant to lymphocytic choriomeningitis virus (LCMV) infection. Their well-characterized differentiation capacity and genetic stability make them a valuable tool in muscle biology research.
| Product Code | C2c12; C2-C12; C12 |
| Species | Mouse |
| Cat.No | ABC-TC0091 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Myoblast |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Muscle |
| Disease | Normal |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Mouse Muscle Cell Lines |
The C2C12 cell line is a versatile model for studying skeletal muscle biology. It enables analysis of native and mutant troponin T (Tnnt3) and contractile protein isoforms on myofilament function, elucidating protein modification effects on muscle physiology. C2C12 cells are widely used to investigate muscle cell differentiation, development, and regeneration. Their derived myotubes facilitate gene modification studies, advancing molecular insights into muscle function and pathology.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
