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Primary Cells

C57BL/6 Mouse Alveolar Epithelial Cells

  • For research use only

Cat No.

ABC-TC3161
Product Type

Mouse Primary Cells
Cell Type

Epithelial
Species

C57BL/6 Mouse
Growth Conditions

37 ℃, 5% CO2
Source Organ

Alveolar
Disease

Normal
Storage

Liquid Nitrogen

C57BL/6 mouse alveolar epithelial cells include AT1 flattened and AT2 cuboidal types, express ACE2, mediate gas exchange, vital for lung disease modeling.

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  • C57BL/6 Mouse Alveolar Epithelial Cells
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Home | Primary Cells | Animal Primary Cells | Mouse Primary cells | C57BL/6 Mouse Alveolar Epithelial Cells

Description

C57BL/6 Mouse Alveolar Epithelial Cells are primary cells isolated from the lung tissue of C57BL/6 mice, a widely used inbred strain in pulmonary research. These cells consist of Type I (AT1) and Type II (AT2) alveolar epithelial cells, which are critical for gas exchange, surfactant production, and lung repair. AT1 cells exhibit a thin, squamous morphology and express markers like AQP5, T1α (Podoplanin), and RAGE, while AT2 cells are cuboidal and express SP-C, SP-B, and ABCG3. Functionally, AT1 cells mediate gas exchange and regulate fluid balance through aquaporin-dependent osmotic permeability and ion transport. Both subtypes express high levels of the ACE2 receptor, a critical entry point for SARS-CoV-2. Their physiological relevance makes them valuable for modeling alveolar-specific pathologies, including viral infections and surfactant dysfunction.

Species

C57BL/6 Mouse
Cat.No

ABC-TC3161
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Epithelial
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Alveolar
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Mouse Primary Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • C57BL/6 Mouse Alveolar Epithelial Cells are widely used in respiratory disease research, including pulmonary fibrosis, emphysema, and COVID-19-related lung injury. They serve as essential models for drug screening, toxicology studies, and regenerative medicine, particularly in assessing surfactant dysfunction and epithelial barrier integrity. These cells are also valuable for studying host-pathogen interactions in viral and bacterial infections. Additionally, their role in wound healing and alveolar repair makes them ideal for investigating stem cell-based therapies in chronic lung diseases.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Frequently Asked Questions

  • What are C57BL/6 Mouse Alveolar Epithelial Cells?

    C57BL/6 Mouse Alveolar Epithelial Cells are a type of epithelial cell derived from the alveoli of the lungs of C57BL/6 mice. They play a crucial role in the structure and function of the alveoli, facilitating gas exchange between the lungs and bloodstream.

  • What is the importance of studying C57BL/6 Mouse Alveolar Epithelial Cells?

    Studying these cells provides insights into lung physiology, respiratory diseases, and toxicology. They serve as an essential model system for investigating lung development, injury, repair, and regeneration, as well as for screening potential therapeutics for respiratory disorders.

  • What research areas are C57BL/6 Mouse Alveolar Epithelial Cells used in?

    Using these cells provides a reproducible and genetically tractable model system for studying lung biology and diseases. Their use allows researchers to investigate specific genetic factors, signaling pathways, and cellular interactions relevant to respiratory health and disease in a controlled experimental setting.

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