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Primary Cells

C57BL/6 Mouse Alveolar Epithelial Cells

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C57BL/6 Mouse Primary Alveolar Epithelial Cells from AcceGen are isolated from tissue of pathogen-free laboratory mice. Mouse Primary Alveolar Epithelial Cells are grown in T25 tissue culture flasks pre-coated with gelatin-based coating solution for 0.5 hour and incubated in AcceGen's Culture Complete Growth Medium for 3-7 days. Cells are detached from flasks and immediately cryo-preserved […]
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Home | Primary Cells | Animal Primary Cells | Mouse Primary cells | C57BL/6 Mouse Alveolar Epithelial Cells
Species

C57BL/6 Mouse
Cat.No

ABC-TC3161
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Epithelial
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Alveolar
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Mouse Primary Cells

Description

C57BL/6 Mouse Alveolar Epithelial Cells are isolated from the lung tissue of C57BL/6 mice and encompass two subtypes: alveolar type I and type II epithelial cells. These cells form the majority of the lung’s internal surface, with type I cells, characterized by expansive squamous morphology and thin cytoplasmic projections, covering over 95% of the lung’s interior. Notably endowed with aquaporins, C57BL/6 Mouse Alveolar Epithelial Cellstype I cells exhibit remarkable osmotic water permeability, potentially influencing ion transport and fluid regulation. Conversely, type II cells, occupying a smaller portion of the lung surface, manage the production, secretion, and recycling of pulmonary surfactant, alongside active Na+ transport for fluid balance. These mouse alveolar epithelial cells also prominently express the ACE2 gene, a conduit exploited by SARS-CoV-2 for cellular entry, as evidenced by robust ACE2 gene expression in our C57BL/6 mouse alveolar epithelial cells.

 

Why choose C57BL/6 Mouse Alveolar Epithelial Cells from AcceGen?

C57BL/6 Mouse Alveolar Epithelial Cells, cryopreserved at passage one, are conveniently supplied frozen, with each vial harboring over 1×106 cells within a 1 ml volume. Authenticated through immunofluorescence using CK-18 antibodies, these cells are mycoplasma, bacteria, yeast, and fungi negative. They are assured to thrive when cultured under AcceGen’s recommended conditions.

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

  • FOR RESEARCH USE ONLY

  • C57BL/6 Mouse Alveolar Epithelial Cells serve as a valuable tool for investigating lung diseases like pulmonary fibrosis. With applications ranging from genomic and proteomic analyses to ex vivo culturing, they offer insights into diverse biological processes. Particularly suited for exploring the lung’s fibrogenic microenvironment and the adaptability of these cells within it, they hold promise for advancing epithelial cell-targeted therapies addressing pulmonary fibrosis and related conditions.

Frequently Asked Questions

  • What are C57BL/6 Mouse Alveolar Epithelial Cells?

    C57BL/6 Mouse Alveolar Epithelial Cells are a type of epithelial cell derived from the alveoli of the lungs of C57BL/6 mice. They play a crucial role in the structure and function of the alveoli, facilitating gas exchange between the lungs and bloodstream.

  • What is the importance of studying C57BL/6 Mouse Alveolar Epithelial Cells?

    Studying these cells provides insights into lung physiology, respiratory diseases, and toxicology. They serve as an essential model system for investigating lung development, injury, repair, and regeneration, as well as for screening potential therapeutics for respiratory disorders.

  • What research areas are C57BL/6 Mouse Alveolar Epithelial Cells used in?

    Using these cells provides a reproducible and genetically tractable model system for studying lung biology and diseases. Their use allows researchers to investigate specific genetic factors, signaling pathways, and cellular interactions relevant to respiratory health and disease in a controlled experimental setting.

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