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Primary Cells

C57BL/6 Mouse Astrocytes-Brain

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Species

C57BL/6 Mouse

Cat.No

ABC-TC033L

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Primary Cells
Size/Quantity

1 vial

Cell Type

Astrocyte

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Source Organ

Brain

Disease

Normal

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Mouse Cells

Description

C57BL/6 Mouse Astrocytes are primary cells isolated from the brain tissue of pathogen-free C57BL/6 mice. These glial cells exhibit a star-shaped morphology with branched processes . As non-proliferative primary cultures, they are cryopreserved at earliest passage and recommended for use within 3-5 passages to maintain functional integrity, as extended subculturing may lead to senescence. Functionally, these astrocytes support neuronal homeostasis through glutamate uptake, ion balance regulation, and metabolic coupling via glucose-lactate shuttling. They actively participate in blood-brain barrier maintenance and modulate neuroinflammation. Each vial contains at least 1×10^6 cells per ml.

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Citation

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Application

  • C57BL/6 Mouse Astrocytes are widely utilized in neuroscience research to model neuroinflammatory responses and neurodegenerative pathologies, including Alzheimer’s disease and multiple sclerosis. These cells serve as powerful tools for studying blood-brain barrier interactions, particularly in co-culture systems with endothelial cells to mimic neurovascular unit dynamics.

Frequently Asked Questions

  • What are C57BL/6 Mouse Astrocytes?

    C57BL/6 Mouse Astrocytes are a type of glial cell found in the central nervous system (CNS) of C57BL/6 mice. They provide support and maintenance to neurons, regulate the extracellular environment, and contribute to various neurological functions.

  • What research areas are C57BL/6 Mouse Astrocytes used in?

    These cells are employed in a wide range of research areas related to neuroscience, including neurodevelopment, neurodegenerative diseases (e.g., Alzheimer’s disease, Parkinson’s disease), neuroinflammation, glioma biology, traumatic brain injury, and drug discovery targeting CNS disorders.

  • What are the advantages of using C57BL/6 Mouse Astrocytes in research?

    Using C57BL/6 Mouse Astrocytes provides a genetically tractable and reproducible model system for studying astrocyte biology and their contributions to CNS function and dysfunction. Their use allows researchers to investigate specific genetic factors, signaling pathways, and cellular interactions relevant to neurological health and disease.

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