C57BL/6 mouse liver sinusoidal endothelial cells (LSECs) are primary cells isolated from the liver tissue of pathogen-free adult C57BL/6 mice. These cells are involved in forming hepatic sinusoids and regulating the permeability of liver blood vessels. LSECs express LYVE-1, CD32b, Factor VIII, and are negative for CD31. They also express FcγRIIb2, PRRs, SRs, and TLRs, reflecting immune function. These cells are cryopreserved at early passage. These cells are applied in studies of liver fibrosis, steatohepatitis, and hepatic inflammation.
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