C57BL/6 Mouse Liver Sinusoidal Endothelial Cells

Description

C57BL/6 Mouse Liver Sinusoidal Endothelial Cells (LSECs) are primary cells isolated from the livers of healthy, pathogen-free adult C57BL/6 mice. As specialized endothelial cells lining hepatic sinusoids, LSECs play a critical role in maintaining liver vascular permeability, filtration, and immune surveillance. They express Factor VIII-related antigen (vWF), as well as key immune receptors, including FcγRIIb2, pattern recognition receptors (PRRs), scavenger receptors (SRs), and Toll-like receptors (TLRs), underscoring their role in pathogen clearance and immune modulation. Cryopreserved at early passages to ensure viability and functionality, these cells are widely used in research on liver fibrosis, non-alcoholic steatohepatitis (NASH), hepatic inflammation, and sinusoidal dysfunction. As specialized liver sinusoidal endothelial cells, these mouse endothelial cells provide a physiologically relevant model for comparing functional attributes across different sinusoidal cells systems in studies of hepatic microvasculature.