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| Product Code | Ca-Ski; CaSki; Caski; CASKI |
| Species | Human |
| Cat.No | ABL-TC0111 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Cervix |
| Disease | Epidermoid Cancer |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Uterine Cancer Cell Lines |
Ca Ski is a human epidermoid cervical carcinoma cell line derived from metastatic lesions in the small bowel mesentery of a 40-year-old Caucasian female patient. This cell line exhibits an epithelial-like, polygonal morphology with adherent growth properties. Its doubling time is approximately 72 hours. Ca Ski harbors complex karyotypic abnormalities, including recurrent chromosomal translocations [der(5)t(5;8)(p13;q23)] and deletions in the 5p11/5q11 regions. A defining feature of this cell line is the integration of high-copy human papillomavirus type 16 (HPV-16) DNA and sequences related to HPV-18. It expresses the β-subunit human chorionic gonadotropin (β-hCG), tumor-associated antigens and glucose-6-phosphate dehydrogenase type B (G6PD-B). Ca Ski demonstrates tumorigenic potential in xenograft models and has been widely used to study cancer metastasis mechanisms, particularly in migration and invasion assays.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
Ca Ski presents a multifaceted utility in biomedical research. In cancer research, Ca Ski cells are particularly relevant for investigating cervical cancer pathogenesis, progression, and potential therapeutic interventions. Moreover, the presence of integrated HPV DNA makes it especially useful for exploring the molecular mechanisms underlying HPV infection and its role in cervical tumor development, shedding light on crucial aspects of these sexually transmitted diseases. Additionally, Ca Ski cells are utilized in assays investigating cell invasion, migration, and metastasis, contributing to a broader understanding of cancer biology and therapeutic targeting.
