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Transfected Stable Cell Lines

CD19 Knockout Raji Cell Line

  • For research use only

Cat No.

ABC-KH010Y
Product Type

Knockout Stable Cell Line
Cell Type

Lymphoblast-like
Species

Human
Host Cell

Raji
Source Organ

Peripheral Blood
Disease

Burkitt’s Lymphoma
Storage

Liquid Nitrogen

CD19 Knockout Raji Cell Line by AcceGen facilitates efficient CAR-T cell therapy validation and B-cell receptor signaling disruption investigations.

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  • CD19 Knockout Raji Cell Line
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Home | Transfected Stable Cell Lines | CD19 Knockout Raji Cell Line

Description

CD19 Knockout Raji Cell Line is engineered from human Burkitt’s lymphoma-derived Raji cells through CRISPR/Cas9-mediated disruption of the Cluster of Differentiation 19 (CD19) gene, a crucial B-cell surface marker involved in B-cell receptor signaling and targeted by CAR-T cell therapies. This knockout model exhibits complete loss of CD19 expression while maintaining Raji cells’ characteristic suspension growth pattern with spherical morphology and Epstein-Barr virus (EBV) positivity. The cell line serves as an invaluable tool for studying B-cell development, evaluating CD19-targeted immunotherapies, and investigating mechanisms of treatment resistance in B-cell malignancies. Maintained at low passage numbers (<P20) to ensure genetic stability, the knockout efficiency is rigorously validated through flow cytometry, genomic PCR, and Sanger sequencing. The cells have been thoroughly tested and confirmed free of contamination from HIV-1, HBV, HCV, Syphilis, mycoplasma, fungi, yeast, and bacteria.

Species

Human
Cat.No

ABC-KH010Y
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphoblast-like
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Peripheral Blood
Disease

Burkitt’s Lymphoma
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Knockout Stable Cell Line
Host Cell

Raji
Gene Info

CD19
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • The CD19 Knockout Raji Cell Line is a specialized model for B-cell research, created by disrupting CD19 expression to study immunotherapy resistance and alternative treatments. It enables precise evaluation of CD19-targeting CAR-T and antibody therapies by eliminating native CD19 interference. This cell line is particularly valuable for investigating treatment escape mechanisms, validating drug specificity, and developing next-generation therapies for B-cell malignancies. Researchers use it for drug screening, biomarker discovery, and mechanistic studies of B-cell signaling pathways. The knockout model provides crucial insights for advancing hematological cancer treatment while maintaining Raji cells’ native biological characteristics.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
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