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Transfected Stable Cell Lines

CD20 Knockout Raji Cell Line

  • For research use only

Cat No.

ABC-KH009Y
Product Type

Knockout Stable Cell Line
Cell Type

Lymphoblast-like
Species

Human
Host Cell

Raji
Source Organ

Peripheral Blood
Disease

Burkitt’s Lymphoma
Storage

Liquid Nitrogen

CD20 Knockout Raji Cell Line by AcceGen is optimized for anti-CD20 drug development and B-cell signaling studies in lymphoma research applications.

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  • CD20 Knockout Raji Cell Line
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Home | Transfected Stable Cell Lines | CD20 Knockout Raji Cell Line

Description

CD20 Knockout Raji Cell Line is generated from human Burkitt’s lymphoma-derived Raji cells using CRISPR/Cas9 technology to disrupt the Cluster of Differentiation 20 (CD20/MS4A1) gene, a key B-cell surface marker targeted by monoclonal antibody therapies. This knockout model exhibits complete loss of CD20 expression while retaining Raji cells’ characteristic suspension growth with spherical morphology and Epstein-Barr virus (EBV) positivity. The cell line serves as an essential tool for studying B-cell signaling, anti-CD20 immunotherapy resistance mechanisms, and drug development for B-cell malignancies. Maintained at low passage numbers (<P20) with genetic stability, the knockout efficiency is validated through flow cytometry, genomic PCR, and Sanger sequencing. The cell line has undergone rigorous quality control and is certified free of contamination from HIV-1, HBV, HCV, Syphilis, mycoplasma, fungi, yeast, and bacteria.

Species

Human
Cat.No

ABC-KH009Y
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphoblast-like
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Peripheral Blood
Disease

Burkitt’s Lymphoma
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Knockout Stable Cell Line
Host Cell

Raji
Gene Info

CD20
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • The CD20 Knockout Raji Cell Line is a valuable tool for studying B-cell malignancies and evaluating CD20-targeted therapies. By eliminating CD20 expression, this engineered cell line enables research into resistance mechanisms, alternative treatment strategies, and next-generation immunotherapies. It serves as an ideal model for testing antibody-based therapies, CAR-T cells, and small-molecule drugs in a controlled environment. Researchers can use this cell line to investigate off-target effects, validate drug specificity, and explore novel biomarkers in B-cell lymphomas. Its applications extend to drug screening, immunotherapy development, and mechanistic studies, providing critical insights for advancing hematologic cancer research.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
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