Cynomolgus Monkey Small Intestinal Epithelial Cells

Description

Cynomolgus Monkey Small Intestinal Epithelial Cells are primary epithelial cells isolated from the small intestine (jejunum or ileum) of healthy Cynomolgus monkeys (Macaca fascicularis) and are often included in cross-tissue comparisons alongside cynomolgus monkey small intestine tissue, neighboring gastrointestinal models such as cynomolgus monkey colon tissue and cynomolgus monkey stomach tissue, as well as epithelial barrier references like cynomolgus monkey trachea tissue. These cells originate from the mucosal lining and are terminally differentiated, including mucus-secreting goblet cells and absorptive enterocytes. They exhibit classic epithelial morphology, form tight junctions, and grow as a monolayer under standard conditions, replicating the physiological intestinal barrier. They express epithelial markers such as E-cadherin, cytokeratin 18, and zonula occludens-1 (ZO-1), as well as transport and immune-related genes including MDR1 (P-gp) and MUC2. Cynomolgus monkeys are genetically and physiologically close to humans, making these cells highly relevant for preclinical studies. They are useful for modeling intestinal absorption, inflammation, barrier integrity, and host-microbe interactions.

Application

• Cynomolgus monkey small intestinal epithelial cells serve as a valuable in vitro model for studying intestinal stem/progenitor cell regeneration and differentiation. These cells enable investigation of mechanisms underlying intestinal disorders such as colitis, IBD, infections, and radiation-induced injury. Insights into stem cell lineage commitment and enterocyte turnover contribute to understanding intestinal homeostasis and support the development of targeted therapies in regenerative medicine.