Discover top-quality products tailored for scientific and medical research. Request a personalized quote today
to enhance your projects.
Species | Human |
Cat.No | ABC-KC0486 |
Product Category | Transfected Stable Cell Lines |
Size/Quantity | 100ug |
Shipping Info | Ice Pack |
Growth Conditions | 37 ℃, 5% CO2 |
Storage | Store DAB2 KO Cell Lysate At -20℃. Please Avoid Repeated Freeze-Thaw Cycles. |
Product Type | CRISPR Knockout Cell Lysate |
Host Cell | HeLa |
DAB2 Knockout Cell Lysate is derived from DAB2 Knockout cell lines such as HeLa and HEK293 which were usually generated via CRISPR/Cas9-mediated gene editing. This lysate was prepared in RIPA buffer from knockout clones, validated either at gene level or protein level by PCR, Sanger Sequencing or Western Blot.assay, Each batch of DAB2 Knockout Cell Lysate includes parental cell lysate as a control to ensure experimental consistency. Customized DAB2 knockout cell lysate are available using customer-specified or provided host cells.
Target
The adaptor molecule disabled-2 (DAB2) gene encodes DAB2 protein. It functions as a multifunctional adaptor by recruiting cargoes to clathrin-coated pits independent of AP-2, regulating TGF-β/SMAD2 and Wnt/β-catenin signaling through stabilization of β-catenin destruction complexes, and suppressing tumorigenesis via ERK/SRC inhibition and LRP6 endocytosis. DAB2 localizes to clathrin-coated pits and plasma membranes.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
For research use only