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Transfected Stable Cell Lines

E2F1 Knockout 293T Cell Line

  • For research use only

Cat No.

ABC-KH022Y
Product Type

Knockout Stable Cell Line
Cell Type

Epithelial
Species

Human
Host Cell

293T
Source Organ

Kidney
Disease

Normal
Storage

Liquid Nitrogen

E2F1 Knockout 293T Cell Line by AcceGen enables critical studies of cell cycle regulation, apoptosis resistance, and cancer progression mechanisms.

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  • E2F1 Knockout 293T Cell Line
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Home | Transfected Stable Cell Lines | E2F1 Knockout 293T Cell Line

Description

E2F1 Knockout 293T Cell Line is generated from human embryonic kidney 293T cells through CRISPR/Cas9-mediated disruption of the E2F Transcription Factor 1 (E2F1) gene, a crucial regulator of cell cycle progression, apoptosis, and DNA damage response. This knockout model exhibits impaired cell cycle control and altered apoptotic signaling while maintaining 293T cells’ characteristic adherent growth with epithelial morphology and high transfection efficiency. The cell line serves as an essential tool for studying cell cycle regulation, oncogenic transformation, and therapeutic resistance mechanisms, particularly in cancer research involving RB/E2F pathway dysregulation. Maintained at low passage numbers (<P20) with genetic stability, the knockout efficiency is validated through genomic PCR, Sanger sequencing, and functional cell cycle analysis. Rigorous quality control confirms the cell line is free of contamination from HIV-1, HBV, HCV, Syphilis, mycoplasma, fungi, yeast, and bacteria.

Species

Human
Cat.No

ABC-KH022Y
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Kidney
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Knockout Stable Cell Line
Host Cell

293T
Gene Info

E2F1
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • E2F1 Knockout 293T Cell Line

  • The E2F1 Knockout 293T Cell Line is a powerful model for studying cell cycle regulation and transcriptional control. This engineered system enables investigation of E2F1’s dual roles in promoting proliferation and apoptosis, particularly in cancer development. Researchers utilize this knockout line to examine cell cycle checkpoint dysregulation and DNA damage responses. The cell line provides a controlled platform for analyzing E2F1-dependent transcriptional networks and exploring therapeutic targets for proliferative disorders and tumor suppression strategies.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
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