HighQC™ Human IPSC-Derived Neural Stem Cell-Alzheimer’s Disease Patient (APOE4 HOM)

Description

HighQC™ Human IPSC-Derived Neural Stem Cells-Alzheimer's Disease Patient (APOE4 HOM) are derived from integration-free induced pluripotent stem cells (iPSCs) of Alzheimer's disease (AD) patients with APOE4 homozygous (HOM) mutation under fully defined neural induction conditions. These human APOE4 neural stem cells express typical markers of cortical neural stem and progenitor cells, such as PAX6, FOXG1, and Nestin, and spontaneously form polarized neural rosette structures when seeded as monolayers. In addition, these cells can generate a range of electrically active cortical excitatory and inhibitory neurons and form functional synapses and circuits in vitro. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.