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HighQC™ Human IPSC-Derived Neural Stem Cell-Alzheimer’s Disease Patient (APOE4 HOM)

  • For research use only

Cat No.

ABC-SC0059T
Product Type

Human iPSCs
Cell Type

Neural Stem Cell
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

iPSC
Disease

Alzheimer’s Disease
Storage

Liquid Nitrogen

HighQC™ Human IPSC-Derived Neural Stem Cell-Alzheimer’s Disease Patient (APOE4 HOM) supports neurodegeneration modeling and APOE4-associated studies.

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  • HighQC™ Human IPSC-Derived Neural Stem Cell-Alzheimer’s Disease Patient (APOE4 HOM)
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Home | Stem Cells | Induced Pluripotent Stem Cells (iPSCs) | Induced pluripotent stem cell-Derived cells (iPSC-Derived cells) | HighQC™ Human IPSC-Derived Neural Stem Cell-Alzheimer’s Disease Patient (APOE4 HOM)

Description

HighQC™ Human IPSC-Derived Neural Stem Cells-Alzheimer’s Disease Patient (APOE4 HOM) are derived from integration-free induced pluripotent stem cells (iPSCs) of Alzheimer’s disease (AD) patients with APOE4 homozygous (HOM) mutation under fully defined neural induction conditions. These human APOE4 neural stem cells express typical markers of cortical neural stem and progenitor cells, such as PAX6, FOXG1, and Nestin, and spontaneously form polarized neural rosette structures when seeded as monolayers. In addition, these cells can generate a range of electrically active cortical excitatory and inhibitory neurons and form functional synapses and circuits in vitro. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.

Product Code

HighQC™ Human IPSC-Derived Neural Stem Cell-Alzheimer’s Disease Patient (APOE4 HOM), hIPSC-NSC-AD-APOE4, Human IPSC Neural Stem Cells Alzheimer APOE4 Homozygous
Species

Human
Cat.No

ABC-SC0059T
Product Category

Stem Cells
Size/Quantity

1 vial
Cell Type

Neural Stem Cell
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

iPSC
Disease

Alzheimer’s Disease
Storage

Liquid Nitrogen
Product Type

Human iPSCs

Application

  • HighQC™ Human IPSC-Derived Neural Stem Cells-Alzheimer’s Disease Patient (APOE4 HOM) are ideal for modeling Alzheimer’s disease (AD) mechanisms in vitro. They enable studies on neuroinflammation, synaptic dysfunction, and APOE4-related tau pathology. The model facilitates high-throughput screening of AD therapeutics targeting neurodegeneration and lipid metabolism.

Citation

When you publish your research, please cite our product as "AcceGen Biotech Cat.# XXX-0000". In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Frequently Asked Questions

  • Were the human iPSCs used to generate these cells created without viral vectors?

    The original iPSCs were reprogrammed from donor tissue using Sendai virus (non-integrating) per CytoTune™ iPS 2.0 protocols. Before cell banking and differentiation, qPCR confirmation ensures complete clearance of the virus, so no residual viral material remains in the iPSC Master/Working Banks or derived neural stem cells.

  • What are the recommended use conditions and licensing terms for HighQC™ Human iPSC-Derived Neural Stem Cells–Alzheimer's Disease Patient (APOE4 HOM)?

    HighQC™ Human iPSC-Derived Neural Stem Cells–Alzheimer’s Disease Patient (APOE4 HOM) are supplied as a ready-to-use research cell product and are recommended for experimental use immediately after recovery. This product is not intended for long-term expansion, and optimization of propagation conditions may require user-specific protocols. The product is supplied for research use only (RUO) and is not intended for clinical or diagnostic applications. To ensure optimal cell performance, the recommended culture medium and coating matrix should be used. In addition, the use of this product is subject to the applicable product licensing and intellectual property terms.

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