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Stem Cells

HighQC™ Human IPSC-Derived Neural Stem Cell MAPT R406W HET

  • For research use only

Cat No.

ABC-SC0070T
Product Type

Human iPSCs
Cell Type

Neural Stem Cell
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

iPSC
Disease

Normal
Storage

Liquid Nitrogen

HighQC™ Human IPSC-Derived Neural Stem Cell MAPT R406W HET models tauopathy for neurodegeneration studies, enabling CRISPR-edited NSC assays in vitro.

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  • HighQC™ Human IPSC-Derived Neural Stem Cell MAPT R406W HET
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Home | Stem Cells | Induced Pluripotent Stem Cells (iPSCs) | Induced pluripotent stem cell-Derived cells (iPSC-Derived cells) | HighQC™ Human IPSC-Derived Neural Stem Cell MAPT R406W HET

Description

HighQC™ Human IPSC-Derived Neural Stem Cells-MAPT R406W HET are a human iPSC-derived neural stem cell line in which a heterozygous R406W mutation (CGG>TGG) has been introduced into the MAPT gene using CRISPR-Cas9 gene editing. One allele carries the mutation, while the other remains wild-type. These neural stem cells express typical markers of cortical neural stem and progenitor cells, such as PAX6, FOXG1, and Nestin. This NSC model can be used to investigate early cellular events in tau-mediated toxicity and serve as a platform for personalized drug testing and transcriptomic analysis. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.
Product Code

HighQC™ Human IPSC-Derived Neural Stem Cell MAPT R406W HET, hIPSC-NSC-MAPT-R406W-HET, Human IPSC Neural Stem Cells MAPT R406W Heterozygous
Species

Human
Cat.No

ABC-SC0070T
Product Category

Stem Cells
Size/Quantity

1 vial
Cell Type

Neural Stem Cell
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

iPSC
Disease

Normal
Storage

Liquid Nitrogen
Product Type

Human iPSCs

Application

  • MAPT R406W heterozygous iPSC-Derived NSCs are suited for modeling dose-dependent tau mutation effects. These cells support in vitro studies of altered tau splicing, phosphorylation, and neuronal structure integrity, contributing to understanding frontotemporal dementia and Alzheimer’s disease-related pathways. Their heterozygous profile allows for nuanced exploration of how varying mutation dosages influence disease progression and therapeutic responsiveness.

Citation

When you publish your research, please cite our product as "AcceGen Biotech Cat.# XXX-0000". In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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