HighQC™ Human IPSC-Derived Neural Stem Cell MAPT R406W HOM

Description

HighQC™ Human IPSC-Derived Neural Stem Cells-MAPT R406W HOM are a human iPSC-derived neural stem cell line in which a homozygous R406W mutation (CGG>TGG) has been introduced into the MAPT gene using CRISPR-Cas9 gene editing. Both alleles carry the R406W mutation. These neural stem cells express typical markers of cortical neural stem and progenitor cells, such as PAX6, FOXG1, and Nestin. The R406W mutation in the MAPT gene is associated with frontotemporal dementia and abnormal tau phosphorylation, leading to neurodegenerative pathology. These MAPT R406W homozygous iPSC-Derived NSCs are suitable for investigating tau aggregation mechanisms, cytoskeletal disruption, and drug screening targeting mutant tau pathology. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.