HighQC™ Human IPSC-Derived Neural Stem Cell-Trisomy X Patient

Description

HighQC™ Human IPSC-Derived Neural Stem Cells-Trisomy X Patient are derived from iPSCs generated from a patient with triple X chromosomal abnormality. All examined iPS cells (20 individual karyotypes) exhibited X trisomy. These cells express typical markers of cortical neural stem and progenitor cells, including PAX6, FOXG1, and Nestin, and can form polarized neural rosette under neural induction conditions. Trisomy X is associated with various neurocognitive symptoms, and this model helps to investigate gene dosage effects, X-chromosome inactivation, and epigenetic dysregulation. These trisomy X iPSC-derived NSCs also provide an opportunity to understand neurodevelopmental disorders in female-specific genomic contexts. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.