HighQC™ Human iPSC Line (RNA, Fibroblast)

Description

HighQC™ Human iPSC Line (RNA, Fibroblast) is a human induced pluripotent stem cell (iPSC) line generated using RNA reprogramming technology. This method utilizes specific RNA molecules (instead of DNA plasmids or viral vectors) to deliver reprogramming factors into fibroblasts, converting them into pluripotent stem cells. The RNA reprogramming approach has the advantage of avoiding genomic integration, thus minimizing the risk of genomic instability and oncogenic mutations. The resulting iPSCs exhibit typical human embryonic stem cell characteristics, including high nucleus-to-cytoplasm ratio and expression of pluripotency markers such as OCT4, SOX2, NANOG, SSEA-4, and TRA-1-60. This cell line is validated for ensuring genetic stability, mycoplasma-free status, and high purity.

Application

• HighQC™ Human iPSC Line (RNA, Fibroblast) is ideal for disease modeling, drug discovery, personalized medicine, and regenerative medicine. This iPSC line can be used to study the molecular mechanisms of human diseases, develop and screen potential drugs, and test drug efficacy and toxicity. Example applications include investigating the pathogenesis of genetic diseases such as inherited heart disease and diabetes, testing potential drug efficacy and toxicity, or developing personalized treatment strategies, particularly in cell therapy and regenerative medicine.