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Human Acne Peripheral Blood Mononuclear Cells

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Acne is a chronic, inflammatory skin condition that causes spots and pimples, especially on the face, shoulders, back, neck, chest, and upper arms.
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Home | Primary Cells | Human Primary Cells | PBMCs | Human Acne Peripheral Blood Mononuclear Cells
Species

Human
Cat.No

ABC-TC4336
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Mononuclear Cell
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Peripheral Blood
Disease

Acne
Storage

Liquid Nitrogen
Product Type

Diseased Human Peripheral Blood Mononuclear Cells

Description

Human Acne Peripheral Blood Mononuclear Cells are a heterogeneous group of immune cells isolated from peripheral blood, including lymphocytes (T cells, B cells, NK cells) and monocytes. Morphologically, PBMCs are typically round or oval. PBMCs play a core role in the pathogenesis of acne, especially in mediating inflammatory responses: monocytes differentiate into macrophages and secrete proinflammatory factors such as IL-1β and TNF-α, and Th17 cell activation can promote IL-17 release, contributing to abnormal keratinization of the pilosebaceous unit and immune responses triggered by Propionibacterium acnes.

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Citation

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Application

  • Human Acne Peripheral Blood Mononuclear Cells can be used to explore immune regulation mechanisms, inflammatory responses, and potential therapeutic targets. In vitro experiments can be conducted to evaluate cytokine secretion (such as IL-1β, IL-6, IL-17, and TNF-α) induced by Propionibacterium acnes or other stimuli, thereby revealing key pathological processes such as Th17/Treg imbalance and NLRP3 inflammasome activation.

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