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Human AKT1 (D323H_C296S) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human AKT1 (D323H_C296S) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0061C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocyte
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human AKT1 (D323H_C296S) BAF3 Cell Line is a genetically engineered model derived from selected murine Ba/F3 parental cell line based on customers’ requirement. This model expresses the human AKT1 gene carrying dual point mutations D323H and C296S, integrated into Ba/F3 cells via lentiviral transduction.
Target
AKT1 is a serine/threonine kinase pivotal in mediating cell proliferation, metabolism, and survival through the PI3K/AKT/mTOR axis. Mutations D323H and C296S both reside in the kinase domain and are associated with altered activity, potentially leading to resistance against AKT-targeted therapies. AcceGen supports the development of customized dual-mutant models to enable detailed functional and pharmacological investigations. Polyclonal or monoclonal is optional.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The AKT1 (D323H_C296S) BAF3 Cell Line provides a robust platform to study oncogenic transformation, mutation-specific signaling dynamics, and the efficacy of targeted inhibitors. It is ideal for therapeutic resistance screening and precision oncology research.

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