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Transfected Stable Cell Lines

Human AKT1 (D323H_C310S) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0030C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocyte
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

The AKT1 (D323H_C310S) BAF3 cell line aids in studying the effects of AKT mutations on cell proliferation, driving the development of new strategies.

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  • Human AKT1 (D323H_C310S) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human AKT1 (D323H_C310S) BAF3 Cell Line

Description

Human AKT1 (D323H_C310S) BAF3 Cell Line is a genetically engineered model derived from selected murine Ba/F3 parental cell line based on customers’ requirement. AKT1 (D323H_C310S) BAF3 mutant cell line is generated by stable integration of exogenous human AKT1 gene harboring dual mutations (D323H and C310S) into Ba/F3 host cells using our optimized transduction of lentiviral vectors.
Target
AKT1 is a central serine/threonine kinase involved in cell survival, metabolism, and proliferation via the PI3K/AKT/mTOR pathway. The C310S and D323H mutations are located in the kinase domain and have been associated with altered kinase activity and tumorigenesis. These mutations facilitate the study of structure-function relationships and resistance mechanisms to AKT inhibitors. AcceGen offers generation of stable overexpression and dual-mutant cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0030C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocyte
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • The AKT1 (D323H_C310S) BAF3 Cell Line serves as a powerful tool to investigate altered AKT signaling and therapeutic response. This model enables mechanistic studies of dual mutation effects, IL-3-independent proliferation, and sensitivity to PI3K/AKT pathway inhibitors. It is utilized for oncology drug screening and personalized therapy research.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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