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Transfected Stable Cell Lines

Human AKT1 (K39R) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0018C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocyte
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

The AKT1 (K39R) BAF3 cell line is an important model for studying the PI3K/AKT signaling pathway, facilitating functional screening and drug research.

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  • Human AKT1 (K39R) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human AKT1 (K39R) BAF3 Cell Line

Description

Human AKT1 (K39R) BAF3 Cell Line is a genetically engineered model derived from selected murine Ba/F3 parental cell line based on customers’ requirement. AKT1 (K39R) BAF3 mutant cell line is generated by stable integration of exogenous human AKT1 gene harboring the K39R point mutation into Ba/F3 host cells using optimized transduction of lentiviral vectors.
Target
AKT1 is a serine/threonine kinase central to cell survival, growth, and metabolism through the PI3K/AKT/mTOR pathway. The K39R mutation, located within the pleckstrin homology (PH) domain, is a kinase-inactivating substitution used to investigate dominant-negative AKT signaling. It serves as a useful tool to dissect the functional relevance of AKT1 activity in growth factor-mediated pathways. AcceGen offers generation of stable overexpression and kinase-dead mutant cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0018C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocyte
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • The AKT1 (K39R) BAF3 Cell Line serves as a powerful tool to investigate AKT1 loss-of-function mechanisms and pathway modulation. This model enables mechanistic studies of PI3K/AKT signaling blockade, IL-3 dependence, and drug response under kinase-inhibited conditions. It is utilized for functional screening of PI3K pathway inhibitors and negative regulatory elements in oncogenic signaling.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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