Human Amyotrophic Lateral Sclerosis (ALS) Peripheral Blood Mononuclear Cells

Description

Human Amyotrophic Lateral Sclerosis (ALS) Peripheral Blood Mononuclear Cells (PBMCs) are isolated from patients with clinically confirmed amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease affecting motor neurons. These human-derived PBMCs contain lymphocytes (T cells, B cells, NK cells) and monocytes that exhibit neuroinflammatory characteristics, including elevated pro-inflammatory cytokine production (IL-6, TNF-α) and increased CD4⁺ T cell activation. The cells demonstrate typical mononuclear morphology with intact surface markers and retain functional immune responses. ALS PBMCs are particularly valuable for studying neuroimmune interactions, as emerging evidence suggests peripheral inflammation contributes to disease progression.