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Human Amyotrophic Lateral Sclerosis (ALS) Peripheral Blood Mononuclear Cells

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Amyotrophic lateral sclerosis (ALS) is a specific disease that causes the death of neurons controlling voluntary muscles.&nbsp,Clinical data may include: Medication (current and historical), Disease Severity, MMSE Score.
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Species

Human

Cat.No

ABC-TC4344

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Primary Cells
Size/Quantity

1 vial

Cell Type

Mononuclear Cell

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Source Organ

Peripheral Blood

Disease

Amyotrophic Lateral Sclerosis

Storage

Liquid Nitrogen

Product Type

Diseased Human Peripheral Blood Mononuclear Cells

Description

Human Amyotrophic Lateral Sclerosis (ALS) Peripheral Blood Mononuclear Cells are a type of mononuclear cell population derived from the peripheral blood of ALS patients, mainly including lymphocytes (T cells, B cells, NK cells) and monocytes. Morphologically, PBMCs are generally round or oval. The core function of PBMCs in ALS patients is to participate in immune regulation and inflammatory response. Their abnormal activation can lead to increased release of proinflammatory cytokines (such as IL-6, TNF-α), reflecting ongoing neuroinflammatory.

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Citation

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Application

  • Human Amyotrophic Lateral Sclerosis (ALS) Peripheral Blood Mononuclear Cells can be used to study the immunopathological mechanism of ALS, biomarker screening and drug efficacy evaluation. In addition, the distinct immune phenotype of PBMCs may offer a potential basis for the early diagnosis of the disease.

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