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Human B2M_FCGRT MDCK Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human B2M_FCGRT MDCK Cell Line
Species

Human
Cat.No

ABC-X0209C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Kidney
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

MDCK

Description

The Human B2M_FCGRT MDCK Cell Line was established by lentiviral transduction to co-express human B2M and FCGRT genes in MDCK cells. MDCK (Madin-Darby Canine Kidney) cells are commonly used as a model of epithelial transport and tight junction formation. Integration of human B2M and FCGRT facilitates transcytosis assays under polarized culture conditions.
Target
B2M and FCGRT are essential for the function of neonatal Fc receptors. This dual-expression model enhances the evaluation of antibody-FcRn interactions, allowing researchers to study cross-species Fc receptor transport in a canine epithelial background. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • Useful for polarized transport studies, FcRn-based IgG trafficking, drug absorption modeling, and evaluation of Fc-engineered therapeutics under epithelial-like conditions.

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