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Transfected Stable Cell Lines

Human BCR ABL (V468F) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human BCR ABL (V468F) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0033C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

The BCR ABL (V468F) BAF3 Cell Line harbors a V468F mutation within the ABL kinase domain, expressed via lentiviral transduction in BAF3 cells. This mutation alters the ATP-binding pocket, contributing to resistance to first-line tyrosine kinase inhibitors. Validation includes qRT-PCR and sequencing.
Target
BCR-ABL V468F mutation enhances oncogenic signaling and is associated with resistance to imatinib. This model enables the evaluation of second- and third-generation TKIs in TKI-resistant CML. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • Used for kinase inhibitor screening, resistance mechanism investigation, and pathway analysis in BCR-ABL-driven leukemia.

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