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Human BCR_ABL (A337T) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human BCR_ABL (A337T) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0333C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human BCR_ABL (A337T) BAF3 Overexpression Cell Line is constructed via lentiviral integration of human BCR-ABL carrying the A337T mutation into Ba/F3 cells. The cells are confirmed at the transcript level and maintained below passage 20.
Target
A337T is a clinically relevant BCR-ABL mutation linked to reduced sensitivity to tyrosine kinase inhibitors. It affects protein conformation and contributes to drug-resistant leukemic phenotypes. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This cell model facilitates detailed investigation of A337T-associated resistance mechanisms and enables preclinical screening of next-gen BCR-ABL inhibitors.

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