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Transfected Stable Cell Lines

Human BCR_ABL (F317L) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human BCR_ABL (F317L) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0217C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

The Human BCR_ABL (F317L) BAF3 Cell Line was generated via lentiviral transduction to stably express the human BCR_ABL gene with the F317L mutation in murine BAF3 cells. This modification enables IL-3-independent proliferation, making it a robust model for kinase inhibitor screening.
Target
BCR_ABL is an oncogenic fusion gene critical in chronic myeloid leukemia. The F317L mutation is associated with resistance to second-generation tyrosine kinase inhibitors. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • Ideal for studying resistance mechanisms and drug efficacy in targeted leukemia therapies, especially those targeting ABL kinase domain mutants.

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