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Transfected Stable Cell Lines

Human BCR_ABL (F317V) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0212C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocytes
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

The BCR-ABL (F317V) BAF3 Cell Line is designed for modeling ABL kinase inhibitor resistance and screening next-generation anti-leukemia agents.

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  • Human BCR_ABL (F317V) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human BCR_ABL (F317V) BAF3 Cell Line

Description

The Human BCR_ABL (F317V) BAF3 Cell Line expresses the human BCR_ABL oncogene with a F317V substitution, introduced via lentiviral transduction into BAF3 cells. The resulting cell line proliferates independently of IL-3, providing a quantitative model for kinase inhibitor response assays.
Target
The F317V mutation in the BCR_ABL gene results in altered binding affinity for ABL kinase inhibitors, contributing to therapeutic resistance. This model replicates the drug resistance phenotype observed in patients with CML undergoing TKI treatment. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0212C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Ideal for high-throughput screening of TKI compounds, resistance mutation characterization, and optimization of novel targeted therapies.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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