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Transfected Stable Cell Lines

Human BCR_ABL (F317V) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human BCR_ABL (F317V) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0212C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

The Human BCR_ABL (F317V) BAF3 Cell Line expresses the human BCR_ABL oncogene with a F317V substitution, introduced via lentiviral transduction into BAF3 cells. The resulting cell line proliferates independently of IL-3, providing a quantitative model for kinase inhibitor response assays.
Target
The F317V mutation in the BCR_ABL gene results in altered binding affinity for ABL kinase inhibitors, contributing to therapeutic resistance. This model replicates the drug resistance phenotype observed in patients with CML undergoing TKI treatment. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • Ideal for high-throughput screening of TKI compounds, resistance mutation characterization, and optimization of novel targeted therapies.

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